Detail of "301-19-9"

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Comparative evaluation of the effect of some flavonoids on changes in the gastric wall of reserpine-treated or immobilized mice

Comparative evaluation of the effect of some flavonoids on changes in the gastric wall of reserpine-treated or immobilized mice. Barnaulov, O. D.; Manicheva, O. A.; Komissarenko, N. F. (Bot. Inst. im. Komarova, Leningrad, USSR). Khim.-Farm. Zh., 17(8), 946-51 (Russian) 1983. CODEN: KHFZAN. ISSN: 0023-1134. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A variety of flavonoids was screened for antiulcer activity in mice with ulcers induced by reserpine or immobilization stress. In the reserpine studies, quercetin [117-39-5] and myricetin [529-44-2] displayed moderate antiulcer activity, and rutin [153-18-4] and hyperoside [482-36-0] had at least some pos. effect. Campherol [520-18-3], robinin [301-19-9], and dactilin [28288-98-4] were inactive. Similar results were obtained in the immobilization expts. It appears that the existence of 2 OH groups ortho to each other is needed for antiulcer activity in flavonoids. Other mol. 117-39-5 and 153-18-4 are just another two chemicals used in this study. structure-biol. activity relations are discussed. .

Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by phenolic plant flavonoids

Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by phenolic plant flavonoids. Huang, Mou Tuan; Wood, Alexander W.; Newmark, Harold L.; Sayer, Jane M.; Yagi, Haruhiko; Jerina, Donald M.; Conney, Allan H. (Dep. Biochem. Drug Metab., Hoffmann-La Roche Inc., Nutley, NJ 07110, USA). Carcinogenesis (London), 4(12), 1631-7 (English) 1983. CODEN: CRNGDP. ISSN: 0143-3334. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Myricetin [529-44-2], robinetin [490-31-3], and luteolin [491-70-3] inhibited the mutagenic activity resulting from the metabolic activation of benzo[a]pyrene (I) [50-32-8] and (±)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene [61443-57-0] by rat liver microsomes. These naturally occurring plant flavonoids and 17 addnl. flavonoids and related derivs. with phenolic hydroxyl groups inhibited the mutagenic activity of (±)-7b,8a-dihydroxy-9a,10a-epoxy-7,8,9,10-tetrahydrobenzo[a]pyren e (B[a]P 7,8-diol-9,10-epoxide-2) [58917-67-2], which is an ultimate mutagenic and carcinogenic metabolite of I. Several flavonoids without phenolic hydroxyl groups of methylated phenolic hydroxyl groups were inactive. The mutagenic activity of 0.05 nmol BP 7,8-diol-9,10-epoxide-2 towards strain TA 100 of Salmonella typhimurium was inhibited 50% by incubation of the bacteria and the diol-epoxide with myricetin (2nmol), luteolin (5 nmol), quercetin [117-39-5] (5 nmol), 7-methoxyquercetin [90-19-7] (5 nmol), rutin [153-18-4] (5 nmol), quercitrin [522-12-3] (5 nmol), delphinidin chloride [528-53-0] (5 nmol), morin [480-16-0] (10 nmol), myricitrin [17912-87-7] (10 nmol), kaempferol [520-18-3] (10 nmol), diosmetin [520-34-3] (10 nmol), fisetin [528-48-3] (10 nmol), or apigenin [520-36-5] (10 nmol). Considerably less antimutagenic activity was obsd. for dihydroquercetin [480-18-2], naringenin [480-41-1], robinin [301-19-9], D-catechin [154-23-4], genistein [446-72-0], kaempferide [491-54-3], and chrysin [480-40-0]. Pentamethoxyquercetin [1247-97-8], tangeretin [481-53-8], nobiletin [478-01-3], 7,8-benzoflavone [604-59-1], 5,6-benzoflavone [6051-87-2], and flavone [525-82-6], which lack free phenolic groups, were inactive. The antimutagenic activity of hydroxylated flavonoids results from their direct interaction with B[a]P 7,8-diol-9,10-epoxide-2 since the rate of disappearance of the diol-epoxide from cell-free solns. in 1:9 dioxane:water was markedly stimulated by myricetin, robinetin, and quercetin. Myricetin was a highly potent inhibitor of the mutagenic activity of bay-region diol-epoxides of I, dibenzo[a,h]pyrene and dibenzo[a,i]pyrene, but higher concns. of myricetin were needed to inhibit the mutagenicity of the chem. less reactive benzo[a]pyrene 4,5-oxide and bay region diol-epoxides of benz[a]anthracene, chrysene, and benzo[c]phenanthrene.