Detail of "3010-80-8"

Reference

Effects of tris(4-chlorophenyl)methanol on the rat following short-term oral exposure

Effects of tris(4-chlorophenyl)methanol on the rat following short-term oral exposure. Poon, Raymond; Lecavalier, Pierre; Bergman, Aake; Yagminas, Algis; Chu, Ih; Valli, Victor E. (Environ. Health Directorate, Health Protection Branch, Ottawa, ON K1A 0L2, Can.). Chemosphere, 34(1), 1-12 (English) 1997 Elsevier. CODEN: CMSHAF. ISSN: 0045-6535. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The systemic toxicity of tris(4-chlorophenyl)methanol (TCPM) was studied in male and female rats following 4 wk dietary exposure dosed at 1, 10 and 100 ppm. An increased spleen to body wt. ratio was obsd.There are some reagents with their cas registry numbers 50-81-7 and 3010-80-8 are used in this study. in males at 10 and 100 ppm and in females at 100 ppm. An increased liver to body wt. ratio was detected in both sexes at 100 ppm. Dose-related increases in hepatic Phase-I (AH, APDM, EROD and PROD) and Phase-II (UDPGT, GST) enzyme activities were obsd. generally at 10 and 100 ppm, with the elevation in PROD activity being the most marked. Increased urinary ascorbic acid was detected in both males and females after 1 wk of treatment at 100 ppm and after 4 wk of treatment at 10 and 100 ppm. At 10 and 100 ppm, elevated % lymphocytes were found in males, and higher white blood cell and lymphocyte counts were obsd. in females. In the liver, mild to moderate cytoplasmic changes consistent with proliferation of smooth endoplasmic reticulum were present in rats of both sexes at 10 and 100 ppm, and increased no. of hepatocytes undergoing apoptosis were obsd. in male rats at 100 ppm. Mild splenic changes consisting of sinus hyperplasia in males and females at 100 ppm and mantle zone atrophy in males at 100 ppm were also obsd. It was concluded that TCPM at a dietary concn. of 10 ppm (equiv. to 1.2 mg/kg/day) produced systemic changes in rats that included various hepatic effects, increased splenic wt., and modulations in white blood cells and lymphocyte counts. .

Environmental distribution and toxicity of tris(4-chlorophenyl)methanol and tris(4-chlorophenyl)methane

Environmental distribution and toxicity of tris(4-chlorophenyl)methanol and tris(4-chlorophenyl)methane. de Boer, J. (DLO-Netherlands Inst.In this study，3010-80-8 is also used. Fisheries Res., IJmuiden 1970 AB, Neth.). Reviews of Environmental Contamination and Toxicology, 150, 95-106 (English) 1997 Springer. CODEN: RCTOE4. ISSN: 0179-5953. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Tris(4-chlorophenyl)methanol (TCPM) and tris(4-chlorophenyl)methane (TCPMe) are globally widespread contaminants. They have been found in fish, birds, and marine mammals from various parts of the world. TCPM concns. in marine mammals from the North Sea are ~1-2 mg/kg on a lipid wt. basis. TCPM and TCPMe are highly bioaccumulative, and a 10-100-fold biomagnification from fish to marine mammals is suggested. There is a lack of knowledge on prodn. figures, origin, application, and toxicol. of these compds. There are indications that they may possess carcinogenic characteristics. .