Detail of "302-22-7"

CAS Number:
302-22-7
Name:
Pregna-4,6-diene-3,20-dione,17-(acetyloxy)-6-chloro-
Superlist Name:
Chlormadinone acetate
Molecular Structure:
Formula:
C₂₃H₂₉ClO₄
Molecular Weight:
404.97
Synonyms:
17-(Acetyloxy)-6-chloropregna-4,6-diene-3,20-dione;6-Chloro-17-alpha-acetoxy-4,6-pregnadiene-3,20-dione;6-Chloro-6-dehydro-17alpha-acetoxyprogesterone;Chlordion;Progesterone, 6-chloro-6-dehydro-17-hydroxy-, acetate;
EINECS:
206-118-0
Density:
1.23 g/cm³
Melting Point:
212 °C
Boiling Point:
512.5 °C at 760 mmHg
Flash Point:
172.5 °C
Appearance:
crystalline solid
Hazard Symbols:
T
Risk Codes:
60-61-40-48
Safety:
53-22-36/37/39-45 Details

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Estrus synchronization in cows using chlormadinone acetate Polfa (CAP): Estrus synchronization in cows using chlormadinone acetate Polfa (CAP). Jedruch, Janusz; Hoppe, Ronan (Inst. Chorob Niezakaznych, Akad. Roln., Warsaw, Pol.). Zesz. Probl. Postepow Nauk Roln., 196, 95-102 (Polish) 1977. CODEN: ZPPRAW. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) The highest incidence of estrus synchronization (95%) was obtained following treatment of cattle with 15 mg chlormadinone acetate (I) [302-22-7]/day, for 18-20 days. Estrus appeared within 3-5 days and the subsequent occurrence of pregnancies following 1st insemination was 30-40%.

Lack of adrenocortical hormone-like effects of chlormadinone acetate in guinea pigs: Lack of adrenocortical hormone-like effects of chlormadinone acetate in guinea pigs. Horiuchi, Toshi; Makino, Masao; Nakayama, Takaharu; Masuda, Shuji; Ito, Kiyoko; Kuboaki, Hiroyoshi; Takahashi, Hiroo; Suzuki, Minoru R. (Pharmacol. Res. Dep., Teikoku Horm. Mfg. Co., Ltd., Kawasaki, Japan). J. Toxicol. Sci., 2(2), 141-7 (English) 1977. CODEN: JTSCDR. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Ingestion 0.01, 0.1 and 1.0% chlormadinone acetate (I) [302-22-7]-contg. diets for 33 days to guinea pigs did not depress adrenal or thymus wt. or leukocyte count or elevate serum cholesterol [57-88-5]. Ingestion of 0.01 and 0.1% cortisol (II) [50-23-7]-contg. diets, however, caused atrophy of adrenal cortex and thymus cortex, hypercholesteremia and the enlargement of liver. Apparently, I has no cortisonelike properties in guinea pigs even at the excessive doses.