Reference

Sleep changes in the rhesus monkey induced by prolonged administration of S

Sleep changes in the rhesus monkey induced by prolonged administration of S. 1694. Balzamo, E.; Vuillon-Cacciuttolo, G. (Serv. Neurophysiol. Clin., Cent. Hosp. Univ., Marseille, Fr.). Psychopharmacology (Berlin), 55(3), 225-31 (French) 1977. CODEN: PSCHDL. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Adult Macaca mulatta were studied during chronic administration (24 days) of S 1694 (I) [30272-08-3] (10 mg/kg, i.m.). This substance induced a significant increase of the 1st awakening (delaying sleep onset) and an enhancement of the duration of rapid-eye-movement (REM) and stage 4 sleep. After withdrawal, the waking effect disappeared, but the increase in stage 4 sleep was maintained for 1 wk and REM enhancement kept rising for 15 days. This observation of long-term action underlined the validity of drug expts. in chronic treatment: I may induce a new type of monoaminergic system regulation.

Effect of 1694 [amineptine hydrochloride] and other dopaminergic agents on circling behavior

Effect of 1694 [amineptine hydrochloride] and other dopaminergic agents on circling behavior. Dankova, Jana; Boucher, Rene; Poirier, Louis J. (Fac. Med., Univ. Laval, Quebec, Que., Can.). Eur. J. Pharmacol., 42(2), 113-21 (English) 1977. CODEN: EJPHAZ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) One h after the administration of amineptine chlorydrate (1694)(I) [30272-08-3] (40 mg/kg) the homovanillic acid [306-08-1] concn. in the striatum was increased but the concns. of dopamine, noradrenaline, serotonin, and 5-hydroxyindoleacetic acid in the striatum, cortex, thalamus, hypothalamus and pons-midbrain of rats were not significantly altered. Unilateral lesioning at the level of the entopeduncular nucleus in cats and rats resulted in spontaneously occurring ipsiversive circling behavior in the two species. However circling was more sustained in cats than in rats. Apomorphine, d-amphetamine, methamphetamine, L-dopa and piribedil (ET-495) exaggerated the ipsiversive circling. I was comparatively more active than L-dopa and ET-495 and less active than apomorphine, d-amphetamine and methamphetamine. Although in higher doses (30-40 mg/kg), I caused increased exploratory activity it was not assocd. with any stereotypy. Its biochem. and pharmacol. effects are comparable to those of d-amphetamine and methamphetamine. Removal of the contralateral (with respect to the side of the entopeduncular lesion) motor cortex in the lesioned cat abolished spontaneous and drug-induced circling movements. Thus, dopaminergic agents act on the striopallidal system of the intact side which is no longer properly counterbalanced by the corresponding system of the lesioned side. Although this exptl. model is useful to det. the degree of dopaminergic activity of various chem. agents it does not duplicate the motor disorders encountered in parkinsonism which are assocd. with a decreased concn. of dopamine.