Detail of "30276-35-8"

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Buxine and buxine hydrochloride, production method and pharmaceutical preparation thereof

All Rights Reserved. Buxine and buxine hydrochloride, production method and pharmaceutical preparation thereof. Hang, Taijun; Zhang, Zhengxing; Liang, Bingwen; Yuan, Houliang; An, Dengkui; Liu, Jie; Fang, Taihui (Peop. Rep. China ). Faming Zhuanli Shenqing Gongkai Shuomingshu CN 1814616 A 9 Aug 2006,43pp. (Chinese). (People's Republic of China). CODEN: CNXXEV. APPLICATION: CN 2010-57543 13 Mar 2006. 30276-35-8 and 860-79-7 are cas registry numbers. These chemicals are also mentioned in this article. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) The title buxine (cyclovirobuxine D 60-95%; cyclobuxine D 1.0-30%; and cyclovirobuxine C 0.5-20%) is prepd. by grinding boxwood into powder; immersing with ammonia water; extg. with trichloromethane; vacuum distg. extractive soln. to obtain residue and recover trichloromethane;dissipating the residue with petroleum ether; extg. with dil. hydrochloric acid;decoloring extractive soln. with active carbon; adjusting pH to 12 with ammonia water; extg. with trichloromethane; vacuum distg. extractive soln. to remove most of solvent to ppt. solid; dissolving ppt. with proper amt. of trichloromethane; cooling and stranding to ppt. crystals; filtering; recrystg. from trichloromethane; and vacuum drying to obtain white to pale yellow product. Buxine hydrochloride is prepd. by charging excessive dry hydrochloric acid gas into trichloromethane contg. buxine; and post-treating to obtain final product. These compds. can be used for prepg. pharmaceutical prepns. such as tablet, capsule, syrups, pill, oral liq., etc. with the advantages of simple prepn. process and low cost. .