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Detail of "30299-08-2"

  • CAS Number:
  • 30299-08-2
  • Name:

  • Clinofibrate

  • Molecular Structure:
  • Formula:
  • C28H36O6
  • Molecular Weight:
  • 468.64
  • Synonyms:
  • 1,1-Bis[4'-(1''-carboxy-1''-methylpropoxy)phenyl]cyclohexane;Butanoic acid,2,2'-[cyclohexylidenebis(4,1-phenyleneoxy)]bis[2-methyl-;Lipoclin;S 8527;
  • Density:
  • 1.163 g/cm3
  • Boiling Point:
  • 619.2 °C at 760 mmHg
  • Flash Point:
  • 200.3 °C
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CAS No.30299-08-2 ClinofibrateCompetitive Product

Supplier:ShangHai Shreal Pharmaceutical Technology Co.,Ltd [ China (Mainland)]

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CAS No.30299-08-2 Clinofibrate

Assay:≥ 98.5%  Appearance:white to whi...

Chemical name:2,2’-(4,4’-cyclohexylidenediphenoxy)-2,2’-dimethyldibutyricacid Structural formula: Molecular formula:C28H36O6 Molecular weight:468.59 Loss on drying:≤ 0.5% ; Residue on ignition:≤ 0.2% ; Heavy metal:≤ 20ppm ; Single contaminant:≤ 0.5% ;

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CAS No.30299-08-2 Clinofibrate

  Package:1Mg;5Mg;10Mg...Storage:Store at RT  Transportation:by air/sea

Supplier:SHAANXI TOP PHARM CHEMICAL CO.LTD [ China (Mainland)]

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CAS No.30299-08-2 Clinofibrate

Assay:99%  Appearance:Off-white po...

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CAS No.30299-08-2 Clinofibrate

30299-08-2

Supplier:Jinan Wedo Industrial Co., Ltd. [ China (Mainland)]

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CAS No.30299-08-2 Clinofibrate

Assay:98.5%+

Supplier:Changzhou Highassay Chemical Co., Ltd [ China (Mainland)]

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CAS No.30299-08-2 Clinofibrate

Supplier:Hangzhou Dayangchem Co., Ltd. [ China (Mainland)]

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SupplierISO 3875Integral
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CAS No.30299-08-2 Clinofibrate

Supplier:Wisdom Pharmaceutical Co., Ltd [ China (Mainland)]

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CAS No.30299-08-2 Clinofibrate

Clinofibrate Chemical name : 2,2'-(Cyclohexylidenebis(4,1-phenyleneoxy))bis(2-methyl)-butanoic acid Molecular Structure : Molecular Formula : C28H36O6 Molecular Weight : 468.59 CAS Registry Number : 30299-08-2 Appearance : White or off white power Lo

Supplier:Huzhou Hengyuan Biochem. Tech. Co., Ltd. [ China (Mainland)]

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Address:C201-207 Kechuangyuan 699# Qingtong Rd., Huzhou City, Zhejiang Prov., China.

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CAS No.30299-08-2 Clinofibrate

Product Name Clinofibrate(CFB) Chemical Name 2,2-(4,4-Cyclohexylidenediphenoxy)-2,2-Dimethyldibutyric Acid CAS NO.: 30299-08-2

Supplier:Wis-Zone Trading Co., Ltd. [ China (Mainland)]

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CAS No.30299-08-2 Clinofibrate

Clinofibrate

Supplier:Cell Molecular Pharmaceutical R&D (Xi’an) Co., Ltd. (CMP) [ China (Mainland)]

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CAS No.30299-08-2 Clinofibrate

CLINOFIBRATE

Supplier:Venturepharm Laboratories Limited [ China (Mainland)]

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CAS No.30299-08-2 Clinofibrate

>95%

Supplier:Hunan Credit-Chem Co., Ltd. [ China (Mainland)]

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CAS No.30299-08-2 Clinofibrate

Clinofibrate CAS:30299-08-2

Supplier:Beijing Zezhongkang pharmaceutical Co,.Ltd [ China (Mainland)]

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CAS No.30299-08-2 Clinofibrate

Molecular Formula: C28H36O6 Formula Weight: 468.58

Supplier:QINGDAO EVER-BRIGHT INDUSTRIAL CO.,LTD [ China (Mainland)]

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CAS No.30299-08-2 Clinofibrate

Supplier:Shaanxi TOP Pharm Chemical Co., Ltd. [ China (Mainland)]

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CAS No.30299-08-2 Clinofibrate

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Supplier:Tianjin Youlong Science&Technology development Co., Ltd. [ China (Mainland)]

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Reference

Effect of clinofibrate on lipid metabolism of aorta in atherosclerotic rats
Effect of clinofibrate on lipid metabolism of aorta in atherosclerotic rats. Shirai, Kohji; Ishikawa, Yoh; Nishide, Toshio; Sasaki, Norihiro; Murano, Shunichi; Matsuoka, Nobuo; Saito, Yasushi; Yoshida, Sho (Sch. Med., Chiba Univ., Chiba 280, Japan). Artery (Fulton, Mich.), 12(3), 145-55 (English) 1983. CODEN: ARTEDR. ISSN: 0098-6127. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Atherosclerotic lesions formed in the aorta of rats given diets contg. propylthiouracil (PTU), vitamin D2 and high cholesterol [57-88-5] for 8 wk. The effect of clinofibrate (I) [30299-08-2], which lowers the plasma lipid level, on lipid metab. in the arterial wall of the atherosclerotic rats was studied. I significantly decreased the high plasma cholesterol level of atherosclerotic rats, which was 823 mg/dL, or ~10-fold that of control rats (85 mg/dL). On treatment with I, the cholesterol level was reduced most in the very-low-d. lipoprotein (VLDL) fraction (d. <1.006). Heparin-releasable lipoprotein lipase [9004-02-8] activity in epididymal adipose tissue, lipoprotein lipase activity in postheparin plasma, and VLDL-triolein-hydrolyzing activity in adipose tissue stromal vessels were higher in I-treated rats than in atherosclerotic rats. Of the enzymes in the arterial wall concerned with cholesterol ester metab., acid cholesterol esterase [9026-00-0] activity was decreased in atherosclerotic rats, and I treatment increased this activity. The ratio of acyl-CoA cholesterol acyltransferase [9027-63-8] activity to neutral cholesterol esterase activity was higher in atherosclerotic rats than in control rats and was lower in I-treated rats than in atherosclerotic rats. Thus, I modifies enzyme activities in such a way as to cause a redn. of cholesterol accumulation in the arterial wall and lowers the plasma VLDL and low-d. lipoprotein cholesterol levels.
Studies on hypolipidemic effects of 1,1-bis[4'-(1''-carboxy-1''-methylpropoxy)phenyl]cyclohexane (S-8527), a new aryloxy compound, in rats
Studies on hypolipidemic effects of 1,1-bis[4'-(1''-carboxy-1''-methylpropoxy)phenyl]cyclohexane (S-8527), a new aryloxy compound, in rats. Nakatani, Hiroshi; Aono, Shunji; Suzuki, Kotaro (Pharm. Div., Sumitomo Chem. Co., Ltd., Takatsukasa, Japan). Oyo Yakuri, 10(2), 277-81 (Japanese) 1975. CODEN: OYYAA2. ISSN: 0369-8033. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) S 8527 (I) [30299-08-2] (10 mg/kg, orally) decreased serum lipid levels in rats. I increased liver wt. at higher doses. The hepatomegalic effect of I was less than that of clofibrate. There was no adverse effect on the body wt. gain in rats receiving 10-300 mg I/kg, while in rats receiving 600 mg I/kg, a decrease of body wt. gain was obsd. I may be more effective and well tolerated than clofibrate. The decrease in serum lipid levels and the increase in liver wt. were returned to normal by cessation of I administration.
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