CAS No.303-53-7,CYCLOBENZAPRINE HCL Suppliers

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Basic Information

Molecular Structure:
CAS No.:	303-53-7
Name:	CYCLOBENZAPRINE HCL
Article Data:	12

Formula:	C20H21 N
Molecular Weight:	275.393
Synonyms:	5H-Dibenzo[a,d]cycloheptene-D5,g-propylamine, N,N-dimethyl- (7CI,8CI);10,11-Dehydroamitriptyline;5-(3-Dimethylaminopropylidene)dibenzo[a,d]cycloheptatriene; 9715 R.P; Amrix;Cyclobenzaprine; MK 130; N,N-Dimethyl-5H-dibenzo[a,d]cycloheptene-D5,g-propylamine; Proheptatrien; Proheptatriene; RP 9715;Ro 4-1577; [3-(5-H-Dibenzo[a,d]cyclohepten-5-ylidene)propyl]dimethylamine
EINECS:	206-145-8
Density:	1.096 g/cm³
Boiling Point:	405.9 °C at 760 mmHg
Flash Point:	177.8 °C
Solubility:	Soluble in water
Appearance:	Solid
Safety:	Poison by ingestion, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NO_x.
PSA:	3.24000
LogP:	5.35580

Synthetic route

: 6682-26-4
cyclobenzaprine N-oxide

: 303-53-7
Cyclobenzaprine

Conditions

Conditions	Yield
With sodium tetrahydroborate In water at 50 - 60℃; chemoselective reaction;	92%

: 109-54-6
3-(Dimethylamino)propyl chloride

: 2222-33-5
dibenzosuberenon

: 303-53-7
Cyclobenzaprine

Conditions

Conditions	Yield
(i) Mg, EtBr, (ii) /BRN= 743171/, (iii) aq. HCl, AcOH; Multistep reaction;

: 18029-54-4
5-[3-(N,N-dimethylamino)propyl]-5H-dibenzo[a,d]cyclohepten-5-ol

: 303-53-7
Cyclobenzaprine

Conditions

Conditions	Yield
With acetic anhydride Heating;

: 109-54-6
3-(Dimethylamino)propyl chloride

(+-)-2-aminomethyl-1-methyl-pyrrolidine: (+-)-2-aminomethyl-1-methyl-pyrrolidine

: 303-53-7
Cyclobenzaprine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: (i) Mg, (ii) /BRN= 743171/, THF 2: Ac2O / Heating View Scheme

: 2222-33-5
dibenzosuberenon

: 303-53-7
Cyclobenzaprine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: (i) Mg, (ii) /BRN= 743171/, THF 2: Ac2O / Heating View Scheme

: 303-53-7
Cyclobenzaprine

: 17822-51-4
1-benzylidene-3-oxo-1-pyrazolidinium-2-ide

: 1-(2-((3-(5H-dibenzo[a,d][7]annulen-5-ylidene)propyl)(methyl)amino)-1-phenylethyl)pyrazolidin-3-one

Conditions

Conditions	Yield
With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; potassium carbonate In acetonitrile at 30℃; for 7h; Irradiation; Schlenk technique; Sealed tube;	98%

: 303-53-7
Cyclobenzaprine

: 16203-86-4
5-Allyliden-dibenzocyclohepten

Conditions

Conditions	Yield
(i) MeI, (ii) aq. NaOH; Multistep reaction;

: 303-53-7
Cyclobenzaprine

: 541-41-3
chloroformic acid ethyl ester

: 16234-95-0
ethyl N-<3-(5H-dibenzocyclohepten-5-ylidene)propyl>-N-methylcarbamate

Conditions

Conditions	Yield
In benzene Heating;

: 303-53-7
Cyclobenzaprine

: 303-50-4
5-[3-(methylamino)propylidene]-5H-dibenzo[a,d]cycloheptene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: benzene / Heating 2: aq. KOH, triethylene glycol / 180 °C View Scheme

: 506-68-3
bromocyane

: 420-04-2
CYANAMID

: 303-53-7
Cyclobenzaprine

: 2455-49-4
5-[3-(n-cyano-N-methyl)aminopropylidene]-5H-dibenzo[a,d]cycloheptene

Conditions

Conditions	Yield
In benzene

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Chemistry

Product Name: Cyclobenzaprine
Synonyms:Cyclobenzaprine ; Cyclobenzaprine HCL ; 10,11-Dehydroamitriptyline ; 1-Propanamine, 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl- ; 3-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamin ; 3-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine ; 5-(3-Dimetilaminopropiliden)-5H-dibenzo-(a,d)-ciclopentene ; 5H-Dibenzo(a,d)cycloheptene-delta5,gamma-propylamine, N,N-dimethyl-
Molecular Structure of Proheptatriene (CAS NO.303-53-7) :
Molecular Formula of Proheptatriene (CAS NO.303-53-7) : C₂₀H₂₁N
Molecular Weight of Proheptatriene (CAS NO.303-53-7) : 275.39
CAS NO: 303-53-7
EINECS 206-145-8
Flash Point: 263.3 °C
Enthalpy of Vaporization: 79.76 kJ/mol
Boiling Point: 511.8 °C at 760 mmHg
Vapour Pressure: 7.65E-11 mmHg at 25°C

Uses

Proheptatriene (CAS NO.303-53-7) is used to alleviate the local muscle spasm and its associated symptoms, such as pain, tenderness and limited mobility.

Toxicity Data With Reference

1.	orl-mus LD50:250 mg/kg	FRPPAO Farmaco, Edizione Pratica. 25 (1970),519.
2.	ipr-mus LD50:90 mg/kg	JMCMAR Journal of Medicinal Chemistry. 6 (1963),338.
3.	ivn-mus LD50:36 mg/kg	FRPPAO Farmaco, Edizione Pratica. 25 (1970),519.

Consensus Reports

EPA Genetic Toxicology Program.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NO_x.