Reference

Effect of 11-deoxycorticosterone acetate on the antineoplastic effect of thiophosphamide, chlorbutin, spirazidine, and prospidin under experimental conditions

Effect of 11-deoxycorticosterone acetate on the antineoplastic effect of thiophosphamide, chlorbutin, spirazidine, and prospidin under experimental conditions. Grushina, A. A.Several substances are used for example 52-24-4 and 56-47-3 which are their cas registry numbers.; Kravchenko, A. I.; Sorkina, Yu. A.; Chernov, V. A. (Moscow, USSR). Tezisy Dokl. - Vses. Konf. Khimioter. Zlokach. Opukholei, 2nd, 169-70. Edited by: Astrakhan, V. I. Akad. Med. Nauk SSSR: Moscow, USSR. (Russian) 1974. CODEN: 34YKAH. DOCUMENT TYPE: Conference CA Section: 2 (Hormone Pharmacology) Doca (I) [56-47-3] (5-15 mg/day) given i.m. to rats for 8 days beginning 4-7 days after inoculation with sarcoma 45 stimulated tumor growth. It also stimulated tumor growth in adrenalectomized animals. I inhibited the antiblastic effects of thiophosphamide [52-24-4], chlorbutin [305-03-3], and prospidin [23476-83-7], particularly in adrenalectomized animals. I weakened the antineoplastic effect of spirazidine [1158-80-1] only in adrenalectomized animals. I decreased the toxicity of thiophosphamide but not that of the other neoplasm inhibitors studied. .

Correlations of alkylating activity and mutagenicity in bacteria of cytostatic drugs

Correlations of alkylating activity and mutagenicity in bacteria of cytostatic drugs. Hemminki, Kari; Kallama, Seija; Falck, Kai (Inst. Occup. Health, Helsinki 00290/29, Finland). Acta Pharmacol. Toxicol., 53(5), 421-8 (English) 1983. CODEN: APTOA6. ISSN: 0001-6683. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The alkylating activity of cytostatic drugs was studied in relation to their mutagenicity and toxicity in Escherichia coli WP2 uvrA. Four classes of directly acting cytostatic drugs were studied: N mustards (N mustard [55-86-7], melphalan [148-82-3], chlorambucil [305-03-3], and phosphoramide mustard [10159-53-2], a metabolite of cyclophosphamide), ethyleneimine derivs. (Thio-TEPA [52-24-4], TEPA [545-55-1], and triethylenemelamine [51-18-3]), busulfan [55-98-1], and halogenated nitrosoureas. The ref. compds. included Me methanesulfonate [66-27-3], ethyleneimine [151-56-4], and methylnitrosourea [684-93-5]. Guanosine [118-00-3] alkylation was detd. by fluorometry. The rate of guanosine and 4-(p-nitrobenzyl)pyridine [1083-48-3] alkylation agreed well. N mustard derivs. and triethylenemelamine were the most potent alkylating agents among the cytostatic drugs; N mustard was 5-10 times more active than Me methanesulfonate. Ethyleneimine derivs., busulfan, and the nitrosoureas were relatively weak alkylating agents. 66-27-3 and 55-98-1 are just another two chemicals used in this study. N mustard and triethylenemelamine were the most potent mutagens in bacteria; they were also among the most toxic drugs studied. .