CAS No.30544-47-9,Etofenamate Suppliers

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Basic Information

Molecular Structure:
CAS No.:	30544-47-9
Name:	Etofenamate
Article Data:	4

Formula:	C18H18 F3 N O4
Molecular Weight:	369.34
Synonyms:	Anthranilicacid, N-(a,a,a-trifluoro-m-tolyl)-, 2-(2-hydroxyethoxy)ethyl ester (8CI);2-(2-Hydroxyethoxy)ethyl flufenamate;2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid 2-(2-hydroxyethoxy)ethylester; B 577; Bay-d 1107; Bayrogel; Etofenamate; Glasel; Reumon; Rheumon;Rheumon gel; TV 485; Traumon Gel; WHR 5020
Density:	1.317g/cm³
Melting Point:	25°C
Boiling Point:	451.1°C at 760 mmHg
Flash Point:	226.6°C
Safety:	Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous routes. Experimental teratogenic and reproductive effects. Used as an anti-inflammatory agent. When heated to decomposition it emits very toxic fumes of F⁻ and NO_x. See also FLUORIDES.
PSA:	67.79000
LogP:	3.68770

Synthetic route

: 64352-85-8
2-(3-Trifluoromethyl-phenylamino)-benzoic acid 2-(2-benzyloxy-ethoxy)-ethyl ester

: 30544-47-9
etofenamate

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol; ethyl acetate

: 64661-77-4
C43H40F6N2O8

: 30544-47-9
etofenamate

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol

: 628-89-7
2-(2-Chloroethoxy)ethanol

: Potassium; 2-(3-trifluoromethyl-phenylamino)-benzoate

: 30544-47-9
etofenamate

Conditions

Conditions	Yield
With potassium carbonate In N,N,N,N,N,N-hexamethylphosphoric triamide

: Potassium; 2-(3-trifluoromethyl-phenylamino)-benzoate

: 30544-47-9
etofenamate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hexamethylphosphoric acid triamide 2: H2 / Pd-C / methanol View Scheme

Raw Materials

64352-85-8

64661-77-4

Total:74 Page 1 of 2 1 2 Next>>

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Chemistry

IUPAC Name: 2-(2-Hydroxyethoxy)ethyl 2-[3-(trifluoromethyl)anilino]benzoate
Molecular Formula:C18H18F3NO4
Molecular Weight: 369.335 g/mol
EINECS: 250-231-8
Boiling Point:130–135°C
Apperance: oil
Partition Coefficient: Log P 4.99 (calc).
Structure of Etofenamate (CAS NO. 30544-47-9):
Product Category : Fluorides.

Uses

Etofenamate(CAS NO. 30544-47-9) is a non-steroidal anti-inflammatory drug (NSAID). NSAIDs relieve pain and reduce the inflammation and fever produced by the body's immune system. Etofenamate has been successfully used for a number a years to treat patients with acute or chronic rheumatic diseases.

Toxicity Data With Reference

1.	orl-rat LD50:292 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 27 (1977),1333.
2.	ipr-rat LD50:373 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 27 (1977),1333.
3.	scu-rat LD50:568 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 27 (1977),1333.
4.	ivn-rat LD50:139 mg/kg	YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. 10 (1982),5225.
5.	orl-mus LD50:743 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 27 (1977),1333.
6.	scu-mus LD50:1897 mg/kg	YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. 10 (1982),5225.
7.	ivn-mus LD50:75 mg/kg	YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. 10 (1982),5225.
8.	scu-rbt LD50:1532 mg/kg	YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. 10 (1982),5225.

Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous routes. Experimental teratogenic and reproductive effects. Used as an anti-inflammatory agent. When heated to decomposition it emits very toxic fumes of F⁻ and NO_x. See also FLUORIDES.

Analytical Methods

Uv max (methanol): 286 (E1%1cm 423). nD25 1.564.

Specification

Etofenamate its cas register number is 30544-47-9. It also can be called n-(Alpha,alpha,alpha-trifluoro-m-tolyl)-anthranilic acid ; 2-(2-hydroxyethoxy) ; 2-(2-Hydroxyethoxy)ethyl 2-[ [3-(trifluoromethyl)phenyl]amino]benzoate ; Rheumon ; TV-485 .
It is hazardous. Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous routes. When Etofenamate (CAS NO. 30544-47-9) is heated to decomposition, it emits very toxic fumes of F⁻ and NO_x. So keep the prodct in cool place, and put it away from fire.