CAS No.30566-92-8,5-(N,N-Dibenzylglycyl)salicylamide Suppliers

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Basic Information

Molecular Structure:
CAS No.:	30566-92-8
Name:	5-(N,N-Dibenzylglycyl)salicylamide
Article Data:	5

Formula:	C₂₃H₂₂N₂O₃
Molecular Weight:	374.439
Synonyms:	Benzamide,5-[[bis(phenylmethyl)amino]acetyl]-2-hydroxy- (9CI);Salicylamide,5-(N,N-dibenzylglycyl)- (8CI);5-(N,N-Dibenzylglycyl)-2-hydroxybenzamide;Benzamide, 5-[2-[bis(phenylmethyl)amino]acetyl]-2-hydroxy-;5-[[Bis(benzyl)amino]acetyl]salicylamide;
EINECS:	250-244-9
Density:	1.249 g/cm³
Melting Point:	168 °C
Boiling Point:	570.3 °C at 760 mmHg
Flash Point:	298.7 °C
Appearance:	light beige powder
Safety:	24/25
PSA:	112.73000
LogP:	3.58360

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Specification

The CAS registry number of Benzamide,5-[2-[bis(phenylmethyl)amino]acetyl]-2-hydroxy- is 30566-92-8. Its EINECS registry number is 250-244-9. The systematic name is 5-(N,N-dibenzylglycyl)-2-hydroxybenzamide. In addition, the molecular formula is C₂₃H₂₂N₂O₃ and the molecular weight is 374.43. What's more, it is a kind of light beige powder. It should be stored in sealed container, and put in a cool and dry place.

Physical properties about Benzamide,5-[2-[bis(phenylmethyl)amino]acetyl]-2-hydroxy- are: (1)ACD/LogP: 5.60; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 5.27; (4)ACD/LogD (pH 7.4): 4.24; (5)ACD/BCF (pH 5.5): 4979.6; (6)ACD/BCF (pH 7.4): 468.18; (7)ACD/KOC (pH 5.5): 12444.59; (8)ACD/KOC (pH 7.4): 1170.04; (9)#H bond acceptors: 5; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 9; (12)Polar Surface Area: 49.85 Å²; (13)Index of Refraction: 1.647; (14)Molar Refractivity: 109.05 cm³; (15)Molar Volume: 299.7 cm³; (16)Polarizability: 43.23×10^-24cm³; (17)Surface Tension: 59.1 dyne/cm; (18)Density: 1.249 g/cm³; (19)Flash Point: 298.7 °C; (20)nthalpy of Vaporization: 88.72 kJ/mol; (21)Boiling Point: 570.3 °C at 760 mmHg; (22)Vapour Pressure: 1.31E-13 mmHg at 25°C.

Preparation of Benzamide,5-[2-[bis(phenylmethyl)amino]acetyl]-2-hydroxy-: it can be prepared by dibenzylamine and 5-bromoacetyl-2-hydroxy-benzoic acid amide. This reaction will need solvent butan-2-one. The reaction time is 40 minutes by heating. The yield is about 53%.

Uses of Benzamide,5-[2-[bis(phenylmethyl)amino]acetyl]-2-hydroxy-: it can be used as pharmaceutical intermediates. And it can react with (3,4-dihydro-2H-[1]quinolyl)-acetone to get 5-{2-[2-(3,4-dihydro-2H-quinolin-1-yl)-1-methyl-ethylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide. This reaction will need reagents H₂ and AcOH, catalysts 10percent PdO/C and 10percent Pt/C, and solvent methanol. The yield is about 37% with ambient temperature.

Benzamide,5-[2-[bis(phenylmethyl)amino]acetyl]-2-hydroxy- can react with (3,4-dihydro-2H-[1]quinolyl)-acetone to get 5-{2-[2-(3,4-dihydro-2H-quinolin-1-yl)-1-methyl-ethylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide

When you are using this chemical, please be cautious about it as the following:
During using it, you should avoid contact with skin and eyes.

Addtionally, the following datas could be converted into the molecular structure:
(1)SMILES: O=C(c1cc(ccc1O)C(=O)CN(Cc2ccccc2)Cc3ccccc3)N
(2)InChI: InChI=1/C23H22N2O3/c24-23(28)20-13-19(11-12-21(20)26)22(27)16-25(14-17-7-3-1-4-8-17)15-18-9-5-2-6-10-18/h1-13,26H,14-16H2,(H2,24,28)
(3)InChIKey: DNLPQXRWAKCKPX-UHFFFAOYAN