Detail of "306-67-2"

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CAS Number:
306-67-2
Name:
1,4-Butanediamine,N1,N4-bis(3-aminopropyl)-, hydrochloride (1:4)
Molecular Structure:
Formula:
C10H26 N4 . 4 Cl H
Molecular Weight:
348.24
Synonyms:
1,4-Butanediamine,N,N'-bis(3-aminopropyl)-, tetrahydrochloride (8CI,9CI); Spermine hydrochloride;Spermine tetrahydrochloride
Density:
0.925g/cm³
Melting Point:
310-311 °C (dec.)(lit.)
Boiling Point:
308.4°Cat760mmHg
Flash Point:
175.6°C
Hazard Symbols:
Risk Codes:
36/38
Safety:
A poison by intraperitoneal route. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NO_x. Details

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Evidence against the view that the central actions of polyamines are indirectly mediated: Evidence against the view that the central actions of polyamines are indirectly mediated. Shaw, Graham G (Dep. Pharm., Univ. Nottingham, Nottingham, Engl.). Biochem. Pharmacol., 26(15), 1450-1 (English) 1977. CODEN: BCPCA6. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Administration of spermine-4HCl (I) [306-67-2] (30 mg base/kg, i.p.) or spermidine-3HCl (II) [334-50-9] (100 mg base/kg, i.p.) to rats did not alter brain levels of acetylcholine [51-84-3], noradrenaline [51-41-2], dopamine [51-61-6], 5-hydroxytryptamine [50-67-9], or GABA [56-12-2]. Although I and II increased blood histamine (III) [51-45-6] levels from 0.37 to 0.72 and 2.66 nmol/mL resp., correction for the contribution of blood III to brain III content showed that brain III levels were not altered. The effects of I and II on the central nervous system were mediated directly.

Effects of spermine and spermidine on single brain stem neurons: Effects of spermine and spermidine on single brain stem neurons. Wedgwood, M. A.; Wolstencroft, J. H. (Med. Sch., Univ. Birmingham, Birmingham, Engl.). Neuropharmacology, 16(6), 445-6 (English) 1977. CODEN: NEPHBW. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Iontophoretic application of spermine-4HCl (I) [306-67-2] and spermidine-3HCl (II) [334-50-9] to neurons from the brain stem of decerebrate cats and anesthetized rats resulted in depression of spontaneous activity in 35%, excitatory effects in 18%, and the remainder were unaffected. The response to I was always in the same direction as that to II although the relative magnitude of the effects varied. I and II may participate in processes which influence neuronal activity.