Detail of "3063-94-3"

Reference

Proteins and muchin adsorption onto fluorinated poly(methacrylates)

Proteins and muchin adsorption onto fluorinated poly(methacrylates). Kojima, Masayoshi; Yokoyama, Yuichi; Kadoma, Yoshinori; Masuhara, Eiichi (Inst. Med. Dent. Eng., Tokyo Med. Dent. Univ., Tokyo, Japan). Iyo Kizai Kenkyusho Hokoku (Tokyo Ika Shika Daigaku), 17, 37-43 (Japanese) 1983. CODEN: IKKHBS. ISSN: 0082-4739. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 35 Trifluoroethyl methacrylate (I) [38785-10-3] was prepd. from trifluoroethanol [75-89-8] and methacryloyl chloride (II) in 14% yield. Hexafluoroisopropyl methacrylate [3063-94-3](III) was prepd. from hexafluoroisopropanol [920-66-1] and II in the presence of Et3N in 15% yield. Homopolymn. of I and its copolymn. with Me methacrylate (IV) were performed in the presence of 0.5% 2,2'-azobis-2,4-dimethyl-4-methoxyvaleronitrile at 0° in sealed tubes. The homopolymn. of III were carried out in the presence of Bz2O2 at 60° in C6H6. Polymers thus obtained were purified by repptn. from C6H6, CH2Cl2, or Me2CO/MeOH. Every polymer obtained was sol. in C6H6 etc., except III-homopolymer [28825-23-2] which was sol. in Et2O. Calf serum albumin (VI), egg white lysozyme (VII) [9001-63-2], and pig gastric mucin (VIII) were labeled with 125I, dissolved in pH 7.30 phosphate buffer soln., and were adsorbed on the polymer films prepd. above. VI adsorption decreased slightly and that of VIII increased significantly with increasing I and III content in the copolymers with IV, whereas VII adsorption was not affected by the film compn.