Detail of "30636-90-9"

Reference

Spectrodensitometric TLC scanning in the determination of Sichuan Zhu Jie ginseng sapogenins

Spectrodensitometric TLC scanning in the determination of Sichuan Zhu Jie ginseng sapogenins. Cai, Ping; Qiu, Xiaoxing; Xiao, Zhuoyin (Inst. Meter. Med., Sichuan Med. Coll., Chengdu, Peop. Rep. China). Sichuan Yixueyuan Xuebao, 15(3), 237-42 (Chinese) 1984. CODEN: CIYPDA. ISSN: 0253-4290. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 63 Sapogenins were isolated from saponins of Zhu-jie ginseng (root of Panax japonicus) grown in Sichuan, China, by H2SO4-EtOH hydrolysis, filtration, CHCl3 extn., and silica gel column chromatog. They were then dissolved in CHCl3-abs. EtOH on silica gel plates with either C6H6-Me2CO (8:2) or C6H6-Et2O (1:1). Plates were then soaked in NH4HSO4 and heated at 105-110° for 12 min for color development. Oleanolic acid (I) [508-02-1] was detd. by densitometry at 525 nm and 20S-protopanaxadiol (II) [30636-90-9], 20S-protopanaxatriol (III) [34080-08-5], and 3b,6a,12b,25-tetrahydroxy-(20d,24R)-epoxydammarane (IV) [69926-31-4] at 400 nm. The sapogenins of Sichuan ginseng were: I 90.5, II 2.4, III 5.2, and IV 1.8%. Differences in the relative amts. of the sapogenins found in Japanese Zhu-jie ginseng are discussed.

Main ginseng saponin metabolites formed by intestinal bacteria

Main ginseng saponin metabolites formed by intestinal bacteria. Hasegawa, Hideo; Sung, Jong Hwan; Matsumiya, Satoshi; Uchiyama, Masamori (Itto Institute Life Science Research, Happy World Inc., Tokyo 183, Japan). Planta Medica, 62(5), 453-457 (English) 1996 Thieme. CODEN: PLMEAA.Some commonly used reagents like 11021-13-9 and 30636-90-9 are used in this experiment. ISSN: 0032-0943. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 63 Ginseng saponin metabolites produced by human intestinal bacteria and the urinary and blood compds. after oral administration of ginseng ext. and its saponins in human and specific pathogen-free rats were examd. to elucidate their metabolites absorbed from the intestines. The main metabolites of ginsenosides Rb1, Rb2, Re, and Rg1 after anaerobic incubation with fecal flora were identified as 20-O-b-D-gluco-pyranosyl-20(S)-protopanaxadiol (I) 20-O-[a-L-arabinopyranosyl(1?6)-b-D-glucopyranosyl]-20(S)-protopan axadiol (II), 20-O-[a-D-arabinofuranosyl(1?6)-b-D-glucopyranosyl]-20(S)-proto-pan axadiol (III), and 20(S)-protopanaxatriol (IV), though the metabolic rate and mode were affected by fermn. media. Furthermore, metabolites I-IV and 20(S)-protopanaxadiol were detected in blood (0.3-5.1mg/mL) and in urine (2.2-96mg/kg/day) to human and of total saponin (1g/kg/day) to rats. .