Detail of "3079-28-5"

Reference

Effect of topical insulin on blood glucose of diabetic mice

Effect of topical insulin on blood glucose of diabetic mice. Kazim, Michael; Weber, Collin; Strausberg, Lisa; LaForet, Genevieve; Reemtsma, Keith (Coll. Physicians Surg., Columbia Univ., New York, NY, USA). Surg. Forum, 35, 64-6 (English) 1984. CODEN: SUFOAX. ISSN: 0071-8041. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 14, 63 Insulin [9004-10-8], applied to the skin of streptozotocin-induced diabetic rats, had a dose-dependent hypoglycemic effect in the range 1-100 units; normoglycemia occurred within 2 h and was maintained for 4 h. With 10 units of insulin and the penetrance enhancers, DMSO [67-68-5] and n-decylmethyl sulfoxide (NDMS) [3079-28-5], the enhancer effect was demoonstrated within 2 h. The hypoglycemic effect of insulin (100 units) plus DMSO or NDMS was improved by placing a nonporous polyethylene patch over the medication. The possible clin. use of topically-applied insulin in the therapy of human diabetes is discussed.

Enhancement of naloxone penetration through human skin in vitro using fatty acids, fatty alcohols, surfactants, sulfoxides and amides

Enhancement of naloxone penetration through human skin in vitro using fatty acids, fatty alcohols, surfactants, sulfoxides and amides.Some chemicals with cas registry numbers like 57-13-6 and 506-44-5 are also used. Aungst, Bruce J.; Rogers, Nancy J.; Shefter, Eli (Biomed. Prod. Dep., E. I. du Pont de Nemours and Co., Wilmington, DE 19898, USA). Int. J. Pharm., 33(1-3), 225-34 (English) 1986. CODEN: IJPHDE. ISSN: 0378-5173. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 Human skin permeation of naloxone (I) [465-65-6] was studied in vitro using various vehicles and penetration enhancers. To screen various chem. as penetration enhancers propylene glycol [57-55-6] contg. 10% adjuvant was used. Fatty acids and fatty alcs. were very effective promoters of I flux. In both the acid and alc. series, max. flux was with C12 adjuvants, and for C18 acids and alcs. unsatd. adjuvants were more effective than satd. ones. Other effective skin penetration enhancers included some nonionic and cationic surfactants, decyl methyl sulfoxide [3079-28-5], Azone [59227-89-3], and N-alkylpyrrolidones. Lauric acid [143-07-7] and lauryl alc. [112-53-8] in iso-PrOH [67-63-0], polyethylene glycol 400 [25322-68-3], and mineral oil vehicles were not as effective in promoting I skin penetration as when dissolved in propylene glycol. Na lauryl sulfate [151-21-3] in propylene glycol slightly increased flux, but a much greater effect was obsd. using a mineral oil vehicle. Concn./enhancement profiles were detd. for lauric acid and lauryl alc. Skin penetration enhancing effects are, to some extent, specific and dependent on the drug, vehicle, enhancer concn. and probably other factors. Possible mechanisms of altering skin permeability are discussed. .