Reference

Quantification of steroids in topical formulations by HPLC

Quantification of steroids in topical formulations by HPLC. Kirschbaum, Joel; Kerr, Lorraine; Perlman, Solomon; O'Laughlin, Richard (Squibb Inst. Med. Res., New Brunswick, NJ 08903, USA). Anal. Chem. Symp. Ser., 23(Adv. Steroid Anal. '84), 445-51 (English) 1985. CODEN: ACSSDR. ISSN: 0167-6350. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 63 A HPLC method for the detn. of halcinonide (I) [3093-35-4], triamcinolone acetonide (II) [76-25-5], III [85197-77-9] and IV [59497-39-1] in various topical formulations, e.g., aerosols, ointments, creams, etc., are described. An octadecylsilane or an octadecylsilane-phenylsilane column with MeCN-H2O as the mobile phase (6:4, 3:7 or 7:3) and variable wavelength UV detection was used. For III, an electrochem. detector was also used. A general system for extn. of these steroids from the formulations was also given.

Topical and other type pharmaceutical formulations containing isosorbide carrier

Topical and other type pharmaceutical formulations containing isosorbide carrier. Chen, James Ling; Battaglia, Jean M. (Squibb, E. R., and Sons, Inc., USA). U.S. US 4082881 4 Apr 1978, 8 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-58. NCL: 424241000. APPLICATION: US 76-753969 23 Dec 1976. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Pharmaceutical formulations, esp. topical forms, for steroids contain an isosorbide (I) (R1 and R2 are H or C1-5 alkyl) in the solubilizer system. Thus, a lotion was prepd. contg. halcinonide [3093-35-4] 0.025, di-Me isosorbide (I, R1 = R2 = Me) [5306-85-4] 45, stearyl alc. 0.5, cetyl alc. 2.6, Tween 20 2.4, Span 40 0.5, methylparaben 0.15, propylparaben 0.02 and water added to 100 g.