Detail of "3113-72-2"

CAS Number:
3113-72-2
Name:
Benzoicacid, 5-methyl-2-nitro-
Superlist Name:
5-Methyl-2-nitrobenzoic acid
Molecular Structure:
Formula:
C₈H₇NO₄
Molecular Weight:
181.15
Synonyms:
m-Toluicacid, 6-nitro- (6CI,7CI,8CI);2-Nitro-5-methylbenzoic acid;3-Methyl-6-nitrobenzoic acid;NSC 38067;
EINECS:
221-481-5
Density:
1.392 g/cm³
Melting Point:
134-136 °C(lit.)
Boiling Point:
363.8 °C at 760 mmHg
Flash Point:
165 °C
Solubility:
insoluble in water
Appearance:
off-white crystalline powder
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety:
26-36/37/39 Details

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Side chain modified 5-deazatolate and 5-deazatetrahydrotolate analogs as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation: Side chain modified 5-deazatolate and 5-deazatetrahydrotolate analogs as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation. 47. N-[4-[[(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-6-yl)methyl]amino]benzoyl- L-glutamic acid, a novel a-ring analog of 2-desamino-5,8-dideazafolic acid. Rosowsky, Andre; Forsch, Ronald A.; Moran, Richard G. (Dana-Farber Cancer Inst., Boston, MA 02115, USA). J.Chemical with cas number 3113-72-2 also plays role. Med. Chem., 35(14), 2626-30 (English) 1992. CODEN: JMCMAR. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 7, 34 2-Aza-2-deamino-5,8-dideazafolic acid (ADDF) (I) was synthesized from 2-amino-5-methylbenzamide via a 4-step sequence consisting of diazotization, benzylic bromination, condensation with di-Me N-(4-aminobenzoyl)-L-glutamate, and ester hydrolysis. 3113-72-2 which is the cas registry number of some chemical is mentioned. I was an inhibitor of recombinant mouse thymidylate synthase; inhibition was competitive with 5,10-methylenetetrahydrofolate as variable substrate (Ki - 2.3 mM). It was a substrate for murine folylpolyglutamate synthetase with kinetic characteristics (Km = 28 mM) comparable to those of aminopterin, and it inhibited the growth of L1210 cells in culture (IC50 - 0.52 mM). The structural modification of the A-ring embodied in ADDF appears to offer a novel unexplored approach to the design of TS inhibitors. ..

Side chain modified 5-deazatolate and 5-deazatetrahydrotolate analogs as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation: Side chain modified 5-deazatolate and 5-deazatetrahydrotolate analogs as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation. 47. N-[4-[[(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-6-yl)methyl]amino]benzoyl- L-glutamic acid, a novel a-ring analog of 2-desamino-5,8-dideazafolic acid. Rosowsky, Andre; Forsch, Ronald A.; Moran, Richard G. (Dana-Farber Cancer Inst., Boston, MA 02115, USA). J.Chemical with cas number 3113-72-2 also plays role. Med. Chem., 35(14), 2626-30 (English) 1992. CODEN: JMCMAR. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 7, 34 2-Aza-2-deamino-5,8-dideazafolic acid (ADDF) (I) was synthesized from 2-amino-5-methylbenzamide via a 4-step sequence consisting of diazotization, benzylic bromination, condensation with di-Me N-(4-aminobenzoyl)-L-glutamate, and ester hydrolysis. 3113-72-2 which is the cas registry number of some chemical is mentioned. I was an inhibitor of recombinant mouse thymidylate synthase; inhibition was competitive with 5,10-methylenetetrahydrofolate as variable substrate (Ki - 2.3 mM). It was a substrate for murine folylpolyglutamate synthetase with kinetic characteristics (Km = 28 mM) comparable to those of aminopterin, and it inhibited the growth of L1210 cells in culture (IC50 - 0.52 mM). The structural modification of the A-ring embodied in ADDF appears to offer a novel unexplored approach to the design of TS inhibitors. ..

Detail of "3113-72-2"

Benzoicacid, 5-methyl-2-nitro-

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CAS No.3113-72-2 5-Methyl-2-nitrobenzoic acid

CAS No.3113-72-2 5-Methyl-2-nitrobenzoic acid

CAS No.3113-72-2 5-Methyl-2-nitrobenzoic acid

CAS No.3113-72-2 5-Methyl-2-nitrobenzoic acid

CAS No.3113-72-2 5-Methyl-2-nitrobenzoic acid

CAS No.3113-72-2 5-Methyl-2-nitrobenzoic acid

CAS No.3113-72-2 5-Methyl-2-nitrobenzoic acid

CAS No.3113-72-2 5-Methyl-2-nitrobenzoic acid

CAS No.3113-72-2 5-Methyl-2-nitrobenzoic acid

CAS No.3113-72-2 5-Methyl-2-nitrobenzoic acid

CAS No.3113-72-2 5-Methyl-2-nitrobenzoic acid

CAS No.3113-72-2 5-Methyl-2-nitrobenzoic acid

CAS No.3113-72-2 5-Methyl-2-nitrobenzoic acid

CAS No.3113-72-2 5-Methyl-2-nitrobenzoic acid

CAS No.3113-72-2 5-Methyl-2-nitrobenzoic acid

CAS No.3113-72-2 5-Methyl-2-nitrobenzoic acid

CAS No.3113-72-2 5-Methyl-2-nitrobenzoic acid

CAS No.3113-72-2 5-Methyl-2-nitrobenzoic acid

CAS No.3113-72-2 5-Methyl-2-nitrobenzoic acid

CAS No.3113-72-2 5-Methyl-2-nitrobenzoic acid

Reference