Detail of "3116-76-5"

Reference

The in vitro activity of 15 penicillins and mecillinam against Neisseria gonorrhoeae

The in vitro activity of 15 penicillins and mecillinam against Neisseria gonorrhoeae. Watts, Barry A.; Phillips, Ian; Stoate, Martin W. (Dep. Microbiol., St. Thomas's Hosp. Med. Sch., London, Engl.). J. Antimicrob. Chemother., 3(4), 331-7 (English) 1977. CODEN: JACHDX. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Min. inhibitory concns. (MIC's) of 15 penicillins and mecillinam were detd. on solid media for 92 strains of N. gonorrhoeae. Regression lines for MIC's of each antibiotic against those of benzylpenicillin Na [69-57-8] were calcd. The order of activity against benzylpenicillin-insensitive strains was ampicillin [69-53-4], amoxycillin [26787-78-0], azidocillin [17243-38-8] ticarcillin [34787-01-4] carbenicillin Na [4800-94-6], sulfocillin [28002-18-8], phenoxymethylpenicillin [87-08-1], methicillin [61-32-5], phenethicillin K [132-93-4], mecillinam [32887-01-7], propicillin K [1245-44-9], flucloxacillin [5250-39-5], nafcillin Na [985-16-0], cloxacillin Na [642-78-4] and dicloxacillin [3116-76-5]. The regressions for flucloxacillin, cloxacillin, and dicloxacillin were indistinguishable as were those of azidocillin, ticarcillin, and carbenicillin. Only ampicillin and amoxycillin showed greater activity than benzylpenicillin against relatively resistant strains.

Study on the pharmacokinetics of dicloxacillin following its parenteral administration under experimental conditions

Study on the pharmacokinetics of dicloxacillin following its parenteral administration under experimental conditions. Vasil'ev, V. K. (All-Union Res. Inst. Antibiot., Moscow, USSR). Antibiotiki (Moscow), 22(5), 450-4 (Russian) 1977. CODEN: ANTBAL. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In both dogs and rats given dicloxacillin (I) [3116-76-5] i.m. or i.v., max. plasma concns. and the duration of therapeutically effective levels of the antibiotic in blood were greater than after oxacillin administration. Within the 1st 24 h after I administration, 62% was excreted in the urine. Highest tissue levels of I were obsd. in the liver, kidney, and lung.