Detail of "313-67-7"

CAS Number:
313-67-7
Name:
Aristolochic acid
Molecular Structure:
Formula:
C₁₇H₁₁NO₇
Molecular Weight:
341.29
Deleted CAS:
61117-05-3,12770-90-0
Synonyms:
8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylicacid;Aristolochia A;Phenanthro[3,4-d]-1,3-dioxole-5-carboxylicacid, 8-methoxy-6-nitro-;Aristolochic acid 1;NSC 11926;NSC 50413;TR 1736;Tardolyt;
EINECS:
206-238-3
Density:
1.571 g/cm³
Melting Point:
260 °C
Boiling Point:
615.5 °C at 760 mmHg
Flash Point:
326 °C
Solubility:
DMSO: soluble
Appearance:
Shiny brown leaflets
Hazard Symbols:
T
Risk Codes:
25
Safety:
7-35-45 Details
Transport Information:
UN 1544 6.1/PG 3

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Aristolochic acid is mutagenic and recombinogenic in Drosophila genotoxicity tests: Aristolochic acid is mutagenic and recombinogenic in Drosophila genotoxicity tests. Frei, H.; Wuergler, F. E.; Juon, H.; Hall, C. B.; Graf, U. (Inst. Toxicol., Swiss Fed. Inst. Technol., Schwerzenbach CH-8603, Switz.). Arch. Toxicol., 56(3), 158-66 (English) 1985. CODEN: ARTODN. ISSN: 0340-5761. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 1 Aristolochic acid (AA)(I) [313-67-7] was tested for genotoxic activity in 3 different assays with D. melanogaster (i-iii). AA induced sex-linked recessive lethals (i) and chromosome losses (ii) in male germ cells. In a newly developed fast assay with somatic cells of larvae (iii), AA induced mutant single spots as well as twin spots. Apparently, in addn. to the mutagenic activity, AA also possesses recombinogenic activity leading to somatic recombination in mitotically active cells. For the detection of the genotoxic activity of AA, the somatic cell assay was faster than the other 2 methods.

Mutagenicity and in vitro metabolism of aristolochic acid: Mutagenicity and in vitro metabolism of aristolochic acid. Schmeiser, H. H.; Pool, B. L.; Wiessler, M. (Inst. Toxicol. Chemother., Ger. Cancer Res. Cent., Heidelberg D-6900, Fed. Rep. Ger.). Biochem. Pharmacol., 34(3), 455-6 (English) 1985. CODEN: BCPCA6. ISSN: 0006-2952. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Under aerobic conditions, >90% of aristolochic acid I (I) [313-67-7] added to rat liver supernatant (9000g) was metabolized whereas no measurable metab. of aristolochic acid II (II) [475-80-9] had occurred after 180 min; under anaerobic conditions, ~60% of II and only 10% of I was metab. When II was incubated with DNA in S-9 mix 2 arom. carcinogen DNA adducts of undetd. structure were formed.