Reference

The stimulus-secretion coupling of amino acid-induced insulin release metabolic interaction of L-asparagine and L-leucine in pancreatic islets

The stimulus-secretion coupling of amino acid-induced insulin release metabolic interaction of L-asparagine and L-leucine in pancreatic islets. Malaisse, W. J.; Malaisse-Lagae, F. 61-90-5 and 127-17-3 are also occured in this study.; Sener, A. (Lab. Exp. Med., Brussels Univ., Brussels B-1000, Belg.). Biochim. Biophys. Acta, 797(2), 194-202 (English) 1984. CODEN: BBACAQ. ISSN: 0006-3002. DOCUMENT TYPE: Journal CA Section: 13 (Mammalian Biochemistry) Section cross-reference(s): 2 Because L-asparagine augments insulin release evoked by L-leucine, the metab. of these 2 amino acids was investigated in rat pancreatic islets. L-Leucine inhibited the uptake and deamidation of L-asparagine, but failed to exert any obvious primary effect on the further catabolism of aspartate derived from exogenous asparagine. L-Asparagine augmented the oxidn. of L-leucine, an effect possibly attributable to activation of 2-ketoisocaproate dehydrogenase. The assocn. of L-asparagine and L-leucine exerted a sparing action on the utilization of endogenous amino acids, so that the integrated rate of nutrients oxidn. was virtually identical in the sole presence of L-leucine and simultaneous presence of L-asparagine and L-leucine, resp. Apparently, the enhancing action of L-asparagine on insulin release evoked by L-leucine is attributable to an increased generation rate of cytosolic NADPH rather than any increase in nutrients oxidn. .

Asparagine-linked glycoprotein biosynthesis: I

Asparagine-linked glycoprotein biosynthesis: I. The enzymic basis for the phosphorylation of lysosomal enzymes. II. Characterization of the enzyme defect in two lectin-resistant cell lines. Reitman, Marc Lionel (Washington Univ., St. Louis, MO, USA).Several reagents with their cas registry numbers 37211-59-9 and 9073-99-8 are used here. 116 pp. Avail. Univ. Microfilms Int., Order No. DA8320570 From: Diss. Abstr. Int. B 1983, 44(5), 1317 (English) 1983. DOCUMENT TYPE: Dissertation CA Section: 14 (Mammalian Pathological Biochemistry) Section cross-reference(s): 13, 15 Abstract Unavailable .