Reference

Chemoprophylactic activity of flubendazole against Brugia pahangi in jirds

Chemoprophylactic activity of flubendazole against Brugia pahangi in jirds. Chusattayanond, W.; Denham, D. A. (London Sch. Hyg. Trop. Med., London WC1E 7HT, UK). J. Parasitol., 70(1), 191-2 (English) 1984. CODEN: JOPAA2. ISSN: 0022-3395. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In jirds, treatment with flubendazole (I) [31430-15-6] (25 mg/kg, s.c.) had prophylactic activity against B. pahangi infections that lasted at least 2 mo.

Chemotherapy of experimental echinococcosis in mice

Chemotherapy of experimental echinococcosis in mice. Vanparijs, O. (Dep. Parasitol., Janssen Pharm., Beerse B-2340, Belg.). Ann. Trop. Med. Parasitol., 80(6), 601-5 (English) 1986. CODEN: ATMPA2. ISSN: 0003-4983. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Mebendazole [31431-39-7] and flubendazole [31430-15-6], administered in the food at 500 ppm for 14 consecutive days, had a marked effect on 1-yr-old hydatid cysts of Echinococcus granulosus in mice infested with protoscolices of human origin. In both treated groups, most of the cysts were collapsed, compared with none in the controls. A small no. of apparently viable cysts was obsd. in both mebendazole- and flubendazole-treated mice. Histol. examn. of collapsed cysts revealed necrosis and limited inflammatory infiltration, but in 1 intact cyst a normal germinal layer was present. The body-wt. decrease of the treated mice, as the cysts collapsed, was interpreted as an excellent indicator of drug efficacy. No drug-related side effects were obsd.