Detail of "315-72-0"

Reference

Comparison between lumogallion and calcon on ion pair extraction-fluorometry and the application for determination of tertiary amines

Comparison between lumogallion and calcon on ion pair extraction-fluorometry and the application for determination of tertiary amines. Syoyama, Masatoshi; Sano, Toshiyuki (Crim. Sci. Lab., Nagoya 460, Japan). Yakugaku Zasshi, 104(4), 351-5 (Japanese) 1984. CODEN: YKKZAJ. ISSN: 0372-7750. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 4 A fluorometric method for the detn. of tertiary amine drugs is described. A CH2Cl2 soln. of lumogallion [4386-25-8] or calcon [2538-85-4] mixt. with the tertiary amine drugs was treated with MeOH and Al(NO3)3 soln. at 60° for ~10 min to form an Al complex, which was detd. at 564 nm with excitation at 488 nm (when lumogallion was used) or at 592 nm with excitation at 537 nm. The reagent formed a complex with tertiary amines, but not with primary amines. Concns. of 2 ′ 108-109 mol/mL carpipramine [5942-95-0], opipramol [315-72-0], benactyzine [302-40-9], chlorpromazine [50-53-3], procaine [59-46-1] and lidocaine [137-58-6] could be detd. Recoveries of added carpipramine and chlorpromazine were 99-103%. Primary and secondary amines at concns. lower than those of test compds. did not interfere with the detn. Reproducibility with a relative std. deviation of 2.6-6.6% was obsd. The method was in good agreement with the UV spectrophotometric method.

Interaction of some neuroleptic and antidepressive agents with human ceruloplasmin

Interaction of some neuroleptic and antidepressive agents with human ceruloplasmin. Loevstad, Rolf A. (Inst. Med. Biochem., Univ. Oslo, Oslo, Norway). Biochem. Pharmacol., 25(16), 1877-9 (English) 1976. CODEN: BCPCA6. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 7 Of 10 neuroleptics and antidepressive agents studied, only promazine (I) [58-40-2] and prothipendyl (II) [303-69-5] were rapidly oxidized by human ceruloplasmin (III). I activity towards imipramine [50-49-7], desipramine [50-47-5], and opipramol [315-72-0] was considerably lower, whereas chloroprothixene [113-59-7], tiothixene [3313-26-6], amitriptyline [50-48-6], protriptyline [438-60-8], and haloperidol [52-86-8] did not react at all. 50-47-5 and 51-41-2 which are cas registry numbers of substances are two of reagents here. A central ring N atom was apparently essential for III activity, and the folded phenothiazine ring system was favorable for a rapid reaction. I and II activated the conversion of noradrenaline [51-41-2] to noradrenochrome [490-89-1] in the presence of III. .