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315-80-0

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Basic Information
CAS No.: 315-80-0
Name: DIBENZEPINE HCL
Molecular Structure:
Molecular Structure of 315-80-0 (DIBENZEPINE HCL)
Formula: C18H21 N3 O . Cl H
Molecular Weight: 331.88
Synonyms: 11H-Dibenzo[b,e][1,4]diazepin-11-one,10-[2-(dimethylamino)ethyl]-5,10-dihydro-5-methyl-, monohydrochloride(8CI,9CI);10-[2-(Dimethylamino)ethyl]-5,10-dihydro-5-methyl-11H-dibenzo(b,e)(1,4)diazepin-11-onehydrochloride; 5-Methyl-10-b-dimethylaminoethyl-10,11-dihydro-11-oxo-5H-dibenzo[b,e][1,4]diazepinehydrochloride; 5-Methyl-10b-dimethylamino-10,11-dihydro-11-oxo-5H-dibenzo[b,e][1,4]diazepinehydrochloride; Dibenzepin hydrochloride; Dibenzepine hydrochloride; Dibenzepinemonohydrochloride; Ecatril; Neodalit; Noveril
Density: g/cm3
Melting Point: 238°
Boiling Point: 451.7°Cat760mmHg
Flash Point: 194.9°C
Safety: Poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. An antidepressant. Many dibenz-azepine compounds have central nervous system effects. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also DIAZEPAM.
PSA: 30.17000
LogP: 3.41900
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Chemistry

IUPAC Name: 5-(2-Dimethylaminoethyl)-11-methylbenzo[b][1,4]benzodiazepin-6-one hydrochloride
Synonyms of Dibenzepine hydrochloride (CAS NO.315-80-0) : 10-[2-(Dimethylamino)ethyl]-5,10-dihydro-5-methyl-11H-dibenzo[b,e][1,4]diazepin-11-one Hydrochloride ; 11H-Dibenzo[b,e][1,4]diazepin-11-one, 10-[2- (dimethylamino)ethyl]-5,10-dihydro-5-methyl-, monohydrochloride ; 11H-Dibenzo[b,e][1,4]diazepin-11-one, 5,10-dihydro-10-[2-(dimethylamino)ethyl]-5-methyl-, monohydrochloride ; 5-Methyl-10b-dimethylaminoethyl-10,11-dihydro-11-oxodibenzo[b,e][1,4]diazepine Hydrochloride
CAS NO:315-80-0
Molecular Formula:C18H22ClN3O     
Molecular Weight :331.8398 
Molecular Structure :
EINECS: 206-255-6
Flash Point: 194.9 °C 
Enthalpy of Vaporization: 71.08 kJ/mol 
Boiling Point: 451.7 °C at 760 mmHg 
Vapour Pressure: 2.39E-08 mmHg at 25°C 

Uses

 Dibenzepine hydrochloride (CAS NO.315-80-0) is used as  intermediate in organic synthesis.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man LDLo oral 72mg/kg (72mg/kg)   Archiv fuer Toxikologie. Vol. 24, Pg. 249, 1969.
mouse LD50 intraperitoneal 64mg/kg (64mg/kg)   Farmakologiya i Toksikologiya Vol. 35, Pg. 274, 1972.
mouse LD50 intravenous 22mg/kg (22mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 70, 1972.
mouse LD50 oral 174mg/kg (174mg/kg)   Drugs in Japan Vol. 6, Pg. 341, 1982.
mouse LD50 subcutaneous 98mg/kg (98mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rat LD50 intraperitoneal 70mg/kg (70mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 70, 1972.
rat LD50 intravenous 22mg/kg (22mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 70, 1972.
rat LD50 oral 220mg/kg (220mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 70, 1972.
rat LD50 subcutaneous 520mg/kg (520mg/kg)   Drugs in Japan Vol. 6, Pg. 341, 1982.
women LDLo oral 66mg/kg (66mg/kg)   Archiv fuer Toxikologie. Vol. 24, Pg. 249, 1969.

 

Safety Profile

Poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. An antidepressant. Many dibenz-azepine compounds have central nervous system effects. When Dibenzepine hydrochloride (CAS NO.315-80-0) is heated to decomposition, it emits very toxic fumes of HCl and NOx. See also DIAZEPAM.

RIDADR 3249
HazardClass 6.1(b)
PackingGroup III