Detail of "316-42-7"

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CAS Number:
316-42-7
Name:
2H-Benzo[a]quinolizine,3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-,hydrochloride (1:2), (2S,3R,11bS)-
Molecular Structure:
Formula:
C29H40 N2 O4 . 2 Cl H
Molecular Weight:
553.63
Synonyms:
2H-Benzo[a]quinolizine,3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[(1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolyl)methyl]-,dihydrochloride (6CI); 2H-Benzo[a]quinolizine,3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-,dihydrochloride, (2S,3R,11bS)- (9CI); Emetan, 6',7',10,11-tetramethoxy-,dihydrochloride; Emetine, dihydrochloride (8CI); (-)-Emetine dihydrochloride;Emetine hydrochloride; Hemometina; l-Emetine dihydrochloride
Density:
g/cm³
Melting Point:
240-250 °C (dec., dry matter)(lit.)
Boiling Point:
600.3 °C at 760 mmHg
Flash Point:
316.9 °C
Solubility:
> 10 mg/ml at 21 C
Appearance:
white powder or crystals
Hazard Symbols:
T+
Risk Codes:
28-36/37/38
Safety:
A poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects: diarrhea, distorted perceptions, dyspnea, hallucinations, hypermotility, nausea or vomiting. A human eye irritant. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x. Details
Transport Information:
UN 1544 6

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The effects of emetine hydrochloride on brain protein synthesis and on dark avoidance response in the goldfish: The effects of emetine hydrochloride on brain protein synthesis and on dark avoidance response in the goldfish. Ohi, S. (Fac. Educ., Tokyo Univ. Educ., Tokyo, Japan). Experientia, 33(9), 1184-5 (English) 1977. CODEN: EXPEAM. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Emetine hydrochloride (I-HCl) [316-42-7] at 100 .mu.g injected intracranially blocked more than 80% of protein synthesis of the brain in the goldfish for at least 4 days, but was not lethal. Testing the effect of I-HCl on dark avoidance go-no go learning, the fish injected with I-HCl showed poorer performance than those injected with distd. water throughout the expt., except on the 1st day, suggesting potentialities of I as a new blocking agent of memory consolidation.

Anti-implantation action of a medicated intrauterine delivery system (MIDS): Anti-implantation action of a medicated intrauterine delivery system (MIDS). Moyer, Dean L.; Thompson, Robert S.; Berger, Israel (Dep. Pathol. Obstet. Gynecol., Univ. South. California Med. Cent., Los Angeles, Calif., USA). Contraception, 16(1), 39-49 (English) 1977. CODEN: CCPTAY. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Emetine-HCl (I-HCl) [316-42-7] compd. as a contraceptive agent when administered locally as a component of a medicated intrauterine delivery system (MIDS) was studied in rabbits. Six combinations of I dose level and device configuration were tested in the rabbit uterus. On the 10th day after mating the number of corpora lutea and implantation sites were recorded and statistically analyzed. The results indicate that I had a marked antiimplantation effect and this was increasingly pronounced with increases in dose level. The surface area of the device is of major importance in determining its overall effectiveness with length being the most critical component of this parameter. When I was present in the uterine lumen, it had no observable effect on implantation in the contralateral horn.