Detail of "31753-17-0"

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Effects of prostaglandins on the structure and permeability of a lipid bilayer

Effects of prostaglandins on the structure and permeability of a lipid bilayer. Viktorov, A. V.; Bezuglov, V. V.; Bergel'son, L. D. (All-Union Cardiol. Res. Cent., Moscow, USSR). Biol. Membr., 1(5), 478-86 (Russian) 1984. CODEN: BIMEE9. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The effects of prostaglandins (PGA2 [13345-50-1], PGE1 [745-65-3], PGE2 [363-24-6], PGF2a [551-11-1], PGE2 Me ester [31753-17-0], 11-fluoro-11-deoxy-PGF2a [67719-38-4], 15-fluoro-15-deoxy-PGF2a [77220-88-3], and 11,9-epoxymethano-PGH2 [56985-40-1]) on the structure and permeability of phosphatidylcholine liposomal membranes were studied by 1H NMR, 13C NMR, and 32P NMR. The prostaglandin mols. were localized in the bilayer at the level of glycerol residues, neither entering the hydrocarbon chain region nor affecting the mobility of phosphocholine polar heads. The shape of the 31P NMR signal from prostaglandin-contg. multilayer liposomes suggested that prostaglandins, even at relatively high concns., did not affect bilayer packing of phospholipid mols. At the same time, concns. of prostaglandins as low as 10-5 M stimulated the transfer of Mn2+ across the phosphatidylcholine membrane. The kinetics of this process was studied by 1H NMR using Mn2+ as a broadening reagent. Prostaglandins formed a 1:1 complex with Mn2+. The relation between the mol. structure of prostaglandins and their ability to induce phosphatidylcholine membrane permeability to divalent cations was indicated. The following series of ionophoric activity of prostaglandins was obtained: 11,9-epoxymethano-PGH2 > PGE1 > 15-fluoro-15-deoxy-PGF2a > PGF2a, PGE2 > PGA2. Biol. implications of the effects were discussed.

The vasorelaxant effect of (±)-15-deoxy-16-hydroxy-16(a/b)-vinyl-prostaglandin E2 (CL 115,129) and its methyl ester (CL 115,347) on the isolated ductus arteriosus preparation

The vasorelaxant effect of (±)-15-deoxy-16-hydroxy-16(a/b)-vinyl-prostaglandin E2 (CL 115,129) and its methyl ester (CL 115,347) on the isolated ductus arteriosus preparation. Lai, F. M.; Tanikella, T. K.; Cervoni, P. (Dep. Cardiovasc. Biol. Res., Am.Several reagents with their cas registry numbers 74608-67-6 and 31753-17-0 are used here. Cyanamid Co., Pearl River, NY 10965, USA). Life Sci., 34(19), 1861-6 (English) 1984. CODEN: LIFSAK. ISSN: 0024-3205. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) CL 115129 [74608-67-6], CL 115347 [73647-73-1], PGE2 [363-24-6], and PGE2 Me ester [31753-17-0] all relaxed the oxygen-indomethacin constricted ductus arteriosus from fetal lambs and rabbits in a dose-dependent manner. Threshold concns. for all compds. were similar (1 ′ 10-12 M). The estd. EC50 values of ~10-8 M for CL 115129 and CL 115347 compared with values of ~10-10 M for PGE2 and its Me ester. Thus, CL 115129 and CL 115347 possessed potent vasorelaxant effects on the ductus arteriosus, although they were less active than PGE2 or its Me ester. .