Detail of "317806-90-9"

Reference

Preparation of 4-amino-1-naphthyl ethers from 1-naphthols

Preparation of 4-amino-1-naphthyl ethers from 1-naphthols. Komoschinski, Joachim; Diehl, Herbert (Bayer Aktiengesellschaft, Germany). PCT Int. Appl. WO 2003020686 A2 13 Mar 2003, 33 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW, AM, AZ, BY, KG, KZ, MD, RU, TJ, TM; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (German). (World Intellectual Property Organization). 317806-90-9 is also in the experiment. CODEN: PIXXD2. CLASS: ICM: C07C213-02. ICS: C07C231-10. APPLICATION: WO 2002-EP9242 19 Aug 2002. PRIORITY: DE 2001-10142461 31 Aug 2001; DE 2001-10154076 2 Nov 2001. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 The invention relates to a method for producing 4-amino-1-naphthyl ethers [I; R1 = (halo)alkyl, arylalkyl, heterocyclyl, etc.; R2 = H, halo, alkyl; R3 = H, halo, alkyl, alkoxy; n = 0-4; R4 = halo, NO2, cyano, fused CHO, alkyl, arylalkyl, hydroxyalkyl, haloalkyl, etc.] by (1) reacting 1-naphthols (II; R2-R4 and n as above) with reactive alkyl compds. (2) treatment the resulting 1-naphthyl ether with hydroxylammonium salts and carboxylic acids to 4-acylamino-1-naphthyl ether followed by, (3) basic elimination of the acyl group.Several reagents such as 317806-90-9 is used here. Thus, 1-naphthol and N-(2-chloroethyl)-morpholine hydrochloride in EtOH were dropwise treated with 50% NaOH at 50° followed by stirring for 3 h at 50° and 1 h reflux to give 93.8% 4-[2-(1-naphthyloxy)ethyl]morpholine. The latter was added under stirring to NH2OH.HCl in polyphosphoric acid followed by stirring for 1 h at 80°-90° and for 3 h at 115° to give 85.1% N-[4-(2-morpholin-4-ylethoxy)-1-naphthyl]acetamide which was stirred with 37% HCl followed by sapon. 839 G of the resulting 4-[2-(4-amino-1-naphthyloxy)ethyl]morpholine dihydrochloride was treated with 50% NaOH to give 620 g 4-[2-(4-amino-1-naphthyloxy)ethyl]morpholine. ..

Preparation of 4-amino-1-naphthyl ethers from 1-naphthols

Preparation of 4-amino-1-naphthyl ethers from 1-naphthols. Komoschinski, Joachim; Diehl, Herbert (Bayer Aktiengesellschaft, Germany). PCT Int. Appl. WO 2003020686 A2 13 Mar 2003, 33 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW, AM, AZ, BY, KG, KZ, MD, RU, TJ, TM; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (German). (World Intellectual Property Organization). 317806-90-9 is also in the experiment. CODEN: PIXXD2. CLASS: ICM: C07C213-02. ICS: C07C231-10. APPLICATION: WO 2002-EP9242 19 Aug 2002. PRIORITY: DE 2001-10142461 31 Aug 2001; DE 2001-10154076 2 Nov 2001. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 The invention relates to a method for producing 4-amino-1-naphthyl ethers [I; R1 = (halo)alkyl, arylalkyl, heterocyclyl, etc.; R2 = H, halo, alkyl; R3 = H, halo, alkyl, alkoxy; n = 0-4; R4 = halo, NO2, cyano, fused CHO, alkyl, arylalkyl, hydroxyalkyl, haloalkyl, etc.] by (1) reacting 1-naphthols (II; R2-R4 and n as above) with reactive alkyl compds. (2) treatment the resulting 1-naphthyl ether with hydroxylammonium salts and carboxylic acids to 4-acylamino-1-naphthyl ether followed by, (3) basic elimination of the acyl group.Several reagents such as 317806-90-9 is used here. Thus, 1-naphthol and N-(2-chloroethyl)-morpholine hydrochloride in EtOH were dropwise treated with 50% NaOH at 50° followed by stirring for 3 h at 50° and 1 h reflux to give 93.8% 4-[2-(1-naphthyloxy)ethyl]morpholine. The latter was added under stirring to NH2OH.HCl in polyphosphoric acid followed by stirring for 1 h at 80°-90° and for 3 h at 115° to give 85.1% N-[4-(2-morpholin-4-ylethoxy)-1-naphthyl]acetamide which was stirred with 37% HCl followed by sapon. 839 G of the resulting 4-[2-(4-amino-1-naphthyloxy)ethyl]morpholine dihydrochloride was treated with 50% NaOH to give 620 g 4-[2-(4-amino-1-naphthyloxy)ethyl]morpholine. ..