Detail of "318-98-9"

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CAS Number:
318-98-9
Name:
Propranolol hydrochloride
Molecular Structure:
Formula:
C₁₆H₂₁NO₂^.HCl
Molecular Weight:
295.84
Deleted CAS:
3506-09-0|146874-86-4
Synonyms:
1-(1-Naphthyloxy)-2-hydroxy-3-isopropylaminopropane hydrochloride;1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol hydrochloride;DL-Propranolol hydrochloride;1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride;2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, hydrochloride;1-(Isopropylamino)-3-(alpha-naphthoxy)-2-propanol hydrochloride;(2-Hydroxy-3-(naphthyloxy)propyl)isopropylammonium chloride;
EINECS:
206-268-7
Melting Point:
163-165 ºC (lit.)
Boiling Point:
434.9 ºC at 760 mmHg
Flash Point:
216.8 ºC
Solubility:
soluble in water
Appearance:
off-white to light-yellow cyrstalline solid
Hazard Symbols:
Xn,Xi
Risk Codes:
22
Safety:
22 Details

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Reference

Differential inhibition of lipolysis in human adipose tissue by adrenergic beta receptor blocking drugs: Differential inhibition of lipolysis in human adipose tissue by adrenergic beta receptor blocking drugs. Frisk-Holmberg, Marianne; Ostman, Jan (Dep. Med., Huddinge Univ. Hosp., Huddinge, Swed.). J. Pharmacol. Exp. Ther., 200(3), 598-605 (English) 1977. CODEN: JPETAB. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 2 The effects of various adrenergic .beta. receptor agonists and antagonists on lipolysis (measured as glycerol release) in human adipose tissue in vitro were studied. The potency rank order of the agonists was isoproterenol-HCl [51-30-9] > norepinephrine-HCl (I) [329-56-6] > salbutamol sulfate [34245-12-0]. 51-30-9 and 13549-60-5 are cas registry numbers of chemicals which are used as reagents here. Adrenergic .beta. receptor blocking drugs inhibited catecholamine-induced lipolysis competetively. Propranolol-HCl [318-98-9] was most effective, followed by metoprolol bitartrate [55250-54-9], alprenolol-HCl [13707-88-5] and practolol-HCl [6996-43-6], whereas butoxamine-HCl [5696-15-1] and H35/25 [13549-60-5] were weak inhibitors. Apparently, the adrenergic receptor mediating lipolysis in human adipose tissue is of the .beta.-1 type. Basal and theophylline-induced lipolysis was decreased when higher concns. of these drugs were used. .

Pressor effects of orally administered beta-adrenergic receptor blocking agents in conscious spontaneously hypertensive rats: Pressor effects of orally administered beta-adrenergic receptor blocking agents in conscious spontaneously hypertensive rats. Kato, Hitoshi; Nishiyama, Hiroshi; Nakao, Kenichiro; Takagi, Keijiro (Fac. Pharm. Sci., Univ. Tokyo, Tokyo, Japan). Jpn. J. Pharmacol., 26(6), 772-5 (English) 1976. CODEN: JJPAAZ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In spontaneously hypertensive rats, dl-YB 2 (I) [36576-14-4] and propranolol-HCl [318-98-9] (90 and 120 mg/kg, orally, resp.) significantly decreased the heart rate and elicited a sustained rise in mean blood pressure. Hydralazine-HCl [304-20-1] (8 and 16 mg/kg, orally) decreased mean blood pressure and tachycardia in hypertensive rats. The pressor effects of d-YB 2 [40940-05-4] were much less than those of I. 6673-35-4 and 30190-87-5 are just another two chemicals used in this study. No marked pressor effects of practolol [6673-35-4] were obsd. .

Detail of "318-98-9"

Propranolol hydrochloride

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CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

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CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

CAS No.318-98-9 Propranolol hydrochloride

Reference