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Detail of "319460-85-0"

  • CAS Number:
  • 319460-85-0
  • Name:

  • Benzamide,N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-

  • Superlist Name:
  • Axitinib
  • Molecular Structure:
  • Formula:
  • C22H18N4OS
  • Molecular Weight:
  • 386.47
  • Deleted CAS:
  • 790713-39-2
  • Synonyms:
  • AG013736;
  • Density:
  • 1.35 g/cm3
  • Melting Point:
  • 213-215 °C
  • Boiling Point:
  • 668.9 °C at 760 mmHg
  • Flash Point:
  • 358.3 °C
  • Appearance:
  • Off-white solid
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CAS No.319460-85-0 AxitinibCompetitive Product

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Axitinib

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CAS No.319460-85-0 Axitinib

Assay:99%Storage:at -20℃ 2 ye...

M.Wt: 386.47 Formula: C22H18N4OS Solubility: DMSO

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CAS No.319460-85-0 Axitinib

Axitinib blocked phosphorylation of VEGFR-2 and VEGFR-3 with average IC50s of 0.2 and 0.1 to 0.3 nM.

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CAS No.319460-85-0 Axitinib

Product name:Axitinib Appearance: off white crystalline powder Purity:99% We produce more APIs:Axitinib ,Masitinib ,Tandutinib ,Raltegravir potassium, Raltegravir,Ezetimibe ,Montelukast sodium , Bosentan,Dexrazoxane, Rasagiline mesylate, Rasagiline, Azacitidine etc.

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10-Hydroxy camptothecin

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Reference

Clinical response to therapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: impact of patient characteristics and Von Hippel-Lindau gene status
All Rights Reserved. Clinical response to therapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: impact of patient characteristics and Von Hippel-Lindau gene status. Rini, Brian I.; Jaeger, Erich; Weinberg, Vivian; Sein, Nancy; Chew, Karen; Fong, Kristen; Simko, Jeffery; Small, Eric J.; Waldman, Frederic M.There are some commonly used reagents with their cas registry numbers 319460-85-0 and 127464-60-2 in this article. (Department of Medicine, The University of California San Francisco, San Francisco, CA, USA). BJU International, 98(4), 756-762 (English) 2006 Blackwell Publishing Ltd. CODEN: BJINFO. ISSN: 1464-4096. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 15 Objective: To describe the relationship among patient characteristics, Von Hippel-Lindau (VHL) gene status and clin. outcome in metastatic renal cell carcinoma (RCC) in patients receiving vascular endothelial growth factor (VEGF)-targeted therapy. Patients And Methods: All patients with metastatic RCC who received therapy with interferon-a plus bevacizumab, SU11248 or AG013736 at the authors' institution were considered. Clin. features were collected and activation status of the VHL gene (VHL) was detd. from baseline paraffin-embedded tumor samples. Tumor response, time to tumor progression (TTP) and overall survival were recorded. Results: Forty-three patients were evaluable for detn. of VHL status and clin. response. There was an objective response in 18 patients (43%; 95% confidence interval 28-59%). The median TTP for the entire cohort was 8.1 mo. There was an improved clin. outcome in patients with the following clin. features: male gender, lack of hepatic metastases, no previous radiation therapy and higher baseline Hb level. Twenty-six patients (60%) had evidence of VHL mutation or promoter methylation; such patients had an objective response rate of 48%, vs 35% in patients with no VHL mutation or methylation. Patients with VHL methylation or a mutation predicted to truncate or shift the VHL reading frame had a median TTP of 13.3 mo, vs 7.4 mo in patients with none of these features (P = 0.06). Conclusion: VEGF-targeted therapy is active in metastatic RCC and the response can be assocd. with certain clin. features. The TTP with VEGF-targeted therapy might be prolonged in patients with VHL methylation or mutations that truncate or shift the VHL reading frame. Further investigation of VHL pathway components is needed to understand the biol. of the response to VEGF-targeted agents in metastatic RCC. .
Method using camptothecin compounds, pyrimidine derivatives, and antitumor agents for treating abnormal cell growth
Method using camptothecin compounds, pyrimidine derivatives, and antitumor agents for treating abnormal cell growth. Denis, Louis J.; Compton, Linda D. (Pfizer Inc, USA). U.Chemical with cas number 319460-85-0 also plays role.S.In this study，319460-85-0 is also used. Pat. Appl. Publ. US 2005272755 A1 8 Dec 2005, 32 pp. (English). (United States of America). CODEN: USXXCO. CLASS: ICM: A61K031-4745. APPLICATION: US 2005-145097 3 Jun 2005. PRIORITY: US 2004-577268P 4 Jun 2004. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) The invention discloses a method for treating abnormal cell growth in a subject, comprising administering to the subject (a) a compd. selected from a camptothecin, a camptothecin deriv., or a pharmaceutically acceptable salt, solvate or prodrug thereof; (b) a pyrimidine deriv. or a pharmaceutically acceptable salt, solvate or prodrug thereof; and (c) an antitumor agent selected from antiproliferative agents, kinase inhibitors, angiogenesis inhibitors, growth factor inhibitors, COX-1 inhibitors, COX-2 inhibitors, mitotic inhibitors, alkylating agents, antimetabolites, intercalating antibiotics, growth factor inhibitors, radiation, cell cycle inhibitors, enzymes, topoisomerase inhibitors, biol. response modifiers, antibodies, cytotoxics, antihormones, antiandrogens and combinations thereof. ..
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