Detail of > 31954-27-5
- CAS Number:
- 31954-27-5
- Name:
Glycine,N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester
- Superlist Name:
- Methyl N-(tert-butoxycarbonyl)glycinate
- Formula:
- C8H15NO4
- Molecular Structure:
![Molecular Structure of 31954-27-5 (Glycine,N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester)](http://www.lookchem.com/300w/2010/0620/31954-27-5.jpg)
- Synonyms:
- Glycine,N-carboxy-, N-tert-butyl methyl ester (6CI);(tert-Butoxycarbonylamino)aceticacid methyl ester;BOC-glycine methyl ester;MethylN-[[(1,1-dimethylethyl)oxy]carbonyl]glycinate;N-(Carbo-tert-butyloxy)glycinemethyl ester;N-(tert-Butoxycarbonyl)glycine methyl ester;N-Boc-glycine methylester;
- Molecular Weight:
- 189.21
- Density:
- 1.072 g/cm3
- Boiling Point:
- 266.8 °C at 760 mmHg
- Flash Point:
- 115.2 °C
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Reference
- A simple, high-yielding synthesis of N-tert-butoxycarbonyl a-amino esters: precursors for a-amino aldehydes
- A simple, high-yielding synthesis of N-tert-butoxycarbonyl a-amino esters: precursors for a-amino aldehydes. McNulty, James; Still, Ian W. J. (J. Tuzo Wilson Res. Lab., Univ. Toronto, Mississauga, ON L5L 1C6, Can.). Synth.Several reagents with their cas registry numbers 2766-43-0 and 31954-27-5 are used here. Commun., 22(7), 979-85 (English) 1992. CODEN: SYNCAV. ISSN: 0039-7911. DOCUMENT TYPE: Journal CA Section: 34 (Amino Acids, Peptides, and Proteins) A general one-pot, two-stage procedure is described for the prepn. of the title compds. Boc-X-OMe (I; Boc = Me3CO2C; X = Phe, Pro, Tyr, Ser, Gly, DL-Trp) from the free amino acids in near quant. yields. Thus, Fischer esterification of the amino acid in dry acidic MeOH contg. mol. sieves gave the intermediate amino ester hydrochlorides, which were treated with Boc2O and excess Et3N in DMF to give I in 98-100% yields. I (R = Phe, Pro) were converted into the corresponding amino aldehydes Boc-X-H with DIBAL. .
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