Detail of "32004-67-4"

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CAS Number:
32004-67-4
Name:
1H-Indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-
Superlist Name:
Sulindac sulfide
Molecular Structure:
Formula:
C₂₀H₁₇FO₂S
Molecular Weight:
340.4112
Synonyms:
Indene-3-aceticacid, 5-fluoro-2-methyl-1-[p-(methylthio)benzylidene]- (8CI);5-Fluoro-2-methyl-1-(p-methylthiobenzylidene)-3-indenylacetic acid;
EINECS:
250-892-2
Density:
1.3 g/cm³
Melting Point:
189-191°C
Boiling Point:
526.3 °C at 760 mmHg
Flash Point:
272.1 °C
Solubility:
DMSO: >22 mg/mL in water
Appearance:
Yellow-orange solid
Hazard Symbols:
Xn
Risk Codes:
22-42/43-63

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Package:46 kg/vacuum...Storage:store at RT Transportation:by sea/air Application:Sulindac sul...

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Thin-layer chromatography and densitometry for the quantitative determination of drugs: Thin-layer chromatography and densitometry for the quantitative determination of drugs. I. Identification and determination of sulindac and its metabolites in plasma. Corti, P.; Lencioni, E.; Zamboni, R.; Lazzeri, L. (Univ. Studi, Siena, Italy). Boll.Some commonly used reagents like 38194-50-2 and 59864-04-9 are used in this experiment. Chim. Farm., 122(5), 229-36 (Italian) 1983. CODEN: BCFAAI. ISSN: 0006-6648. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 64 Sulindac [38194-50-2], its thio metabolite [32004-67-4], and its sulfone metabolite [59864-04-9] were extd. from plasma or from pure aq. soln. with CH2Cl2 and sepd. by thin-layer chromatog., using C6H6-CHCl3 (1:2) as mobile phase in the 1st direction and CH2Cl2 in the 2nd direction. Densitometric detection and quantitation were at 300 mm. The recoveries, slightly less from H2O than from plasma, were satisfactory. The method was able to measure plasma concns. of the 3 compds. of 30.75 mg/mL. .

Aldose reductase inhibition by 5-fluoro-2-methyl-1-[(4-[methylthio]phenyl)methylene]-1H-indene-3-aceti c acid: Aldose reductase inhibition by 5-fluoro-2-methyl-1-[(4-[methylthio]phenyl)methylene]-1H-indene-3-aceti c acid. Dvornik, Dushan M.; Simard-Duquesne, Nicole (Ayerst, McKenna and Harrison, Inc., Can.). U.S. US 4423074 A 27 Dec 1983, 4 pp. Cont.-in-part of U.S. 4,307,114. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-19. NCL: 424317000. APPLICATION: US 81-332566 21 Dec 1981. PRIORITY: US 80-160873 19 Jun 1980. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) The title compd. (I) [32004-67-4] is suggested as possibly useful in the therapy and prophylaxis of diabetes-assocd. complications such as cataracts, neuropathy, nephropathy, and retinopathy. In vitro at 10-6M, I inhibits aldose reductase [9028-31-3] activity by 50%. 9028-31-3 and 32004-67-4 which are cas registry numbers of substances are two of reagents here. This is the key enzyme in the sorbitol pathway; sorbitol has been assocd. with the above complications of diabetes. Previously described expts. are summarized which indicate that I decreases the accumulation of galactitol in the lenses and sciatic nerves of rats fed galactose. .