Detail of "321-97-1"

Reference

Comparison of brown adipose tissue thermogenesis induced by congeners and isomers of phenylpropanolamine

Comparison of brown adipose tissue thermogenesis induced by congeners and isomers of phenylpropanolamine. Wellman, P. J.; Marmon, M. M. (Dep. Psychol., Texas A and M Univ., College Station, TX 77843, USA). Life Sci., 37(11), 1023-8 (English) 1985. CODEN: LIFSAK. ISSN: 0024-3205. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effects of i.p. injection of several phenethyl congeners and isomers on in vivo interscapsular brown adipose tissue (IBAT) temp. in adult male rats were compared. Comparable increases in IBAT thermogenesis were obsd. in rats treated with either d-amphetamine ((d)-AMP) [51-64-9] or dl-AMP [300-62-9] and in rats treated with either l-phenylpropranolamine ((l)-PPA) [492-41-1] or dl-PPA [14838-15-4]. d-PPA [37577-28-9] was only half as potent as l-PPA; similarly d-ephedrine ((d)-EPH) [321-98-2] was only half as potent as l-EPH [299-42-3]. There were no significant differences between the changes in IBAT thermogenesis obsd. in rats treated with d-pseudoephedrine [90-82-4] and its l-isomer [321-97-1] and d-norpseudoephedrine [492-39-7] and its l-isomer [37577-07-4]. The approx. order of potency (calcd. as the av. of the temp. changes for the isomers) for the congeners was AMP > PPA > EPH > norpseudoephedrine methoxyphenamine [93-30-1] > pseudoephedrine. The implications of these data for the wt.-reducing activity of these compds. is discussed.

A Novel X-ray Powder Diffractometric Method for Studying the Reaction between Pseudoephedrine Enantiomers

A Novel X-ray Powder Diffractometric Method for Studying the Reaction between Pseudoephedrine Enantiomers. Duddu, Sarma P.; Khin-Khin, Aye; Grant, David J. W.; Suryanarayanan, Raj (Department of Pharmaceutics College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA). Journal of Pharmaceutical Sciences, 86(3), 340-345 (English) 1997 American Chemical Society. CODEN: JPMSAE. ISSN: 0022-3549. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) The opposite enantiomers of pseudoephedrine were obsd. to react in the solid state to form the racemic compd. A novel powder X-ray diffractometric method was developed for studying the kinetics and mechanism of this reaction. The powder X-ray diffraction patterns of the enantiomers were identical, but the racemic compd. exhibited a different pattern because of its different crystal structure.Some commonly used reagents like 90-82-4 and 321-97-1 are used in this experiment. The powder patterns of the enantiomers and the racemic compd. revealed that the 4.62 and 4.25 ? lines were unique to the enantiomers and the racemic compd., resp. Teflon holders were filled with equimolar mixts. of the two enantiomers, and the integrated intensities of the 4.62 and 4.25 ? lines were measured at 30-min intervals over a period of 8 h. Thus, the disappearance of the cryst. enantiomers and the appearance of the cryst. racemic compd. were quantified simultaneously. The rate of disappearance of the cryst. enantiomers followed a diffusion-controlled reaction model originally proposed by Jander in 1927. During the kinetic expt., the sum of the wt. fractions of the enantiomers and the racemic compd. progressively decreased from an initial value of unity suggesting the existence of an intermediate noncryst. phase. The presence of the noncryst. phase was confirmed by a steady increase in the background of the X-ray patterns. Thus, the unique ability of the X-ray method to quantify only the cryst. phases has demonstrated the existence of a non-cryst. amorphous intermediate in this solid-solid reaction. .