CAS No.322-46-3,Pyrido[2,3-b]pyrazine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	322-46-3
Name:	Pyrido[2,3-b]pyrazine
Article Data:	9

Formula:	C₇H₅N₃
Molecular Weight:	131.137
Synonyms:	1,4,5-Triazanaphthalene;5-Azaquinoxaline;NSC 73508;
EINECS:	206-294-9
Density:	1.27 g/cm³
Melting Point:	139-143 °C
Boiling Point:	253.9 °C at 760 mmHg
Flash Point:	115.9 °C
Appearance:	brown to dark green crystalline powder
Hazard Symbols:	Xn
Risk Codes:	36/37/38-20/21/22
Safety:	36/37/39-26
PSA:	38.67000
LogP:	1.02480

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Specification

This chemical is called Pyrido[2,3-b]pyrazine, and its systematic name is 131.13. With the molecular formula of C₇H₅N₃, its molecular weight is 322-46-3. The CAS registry number of this chemical is 322-46-3. Additionally, its product category is Fused Ring Systems.

Other characteristics of the Pyrido[2,3-b]pyrazine can be summarised as followings: (1)ACD/LogP: -0.04; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.04; (4)ACD/LogD (pH 7.4): -0.04; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 22.66; (8)ACD/KOC (pH 7.4): 22.66; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 38.67 Å²; (13)Index of Refraction: 1.665; (14)Molar Refractivity: 38.36 cm³; (15)Molar Volume: 103.2 cm³; (16)Polarizability: 15.21×10^-24cm³; (17)Surface Tension: 65.4 dyne/cm; (18)Density: 1.27 g/cm³; (19)Flash Point: 115.9 °C; (20)Enthalpy of Vaporization: 47.15 kJ/mol; (21)Boiling Point: 253.9 °C.

Production method of this chemical: The Pyrido[2,3-b]pyrazine could be obtained by the reactants of [1,4]dioxane-2,3-diol and pyridine-2,3-diamine. This reaction needs the solvent of ethanol. The yield is 87 %. In addition, this reaction should be taken for 30 minutes at ambient temperature.

The Pyrido[2,3-b]pyrazine could be obtained by the reactants of [1,4]dioxane-2,3-diol and pyridine-2,3-diamine

Uses of this chemical: The Pyrido[2,3-b]pyrazine could react with 1-chloromethanesulfonyl-4-methyl-benzene, and obtain the 1,1a,1b,2-tetrahydro-1,2-bis(p-tolylsulfonyl)bisazirino[1.2-a:2'.1'-c]pyrido[2.3-e]pyrazine. This reaction needs the reagent of KOH, and the solvent of dimethylsulfoxide. The yield is 32 %.

The Pyrido[2,3-b]pyrazine could react with 1-chloromethanesulfonyl-4-methyl-benzene, and obtain the 1,1a,1b,2-tetrahydro-1,2-bis(p-tolylsulfonyl)bisazirino[1.2-a:2'.1'-c]pyrido[2.3-e]pyrazine

When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin. You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1.SMILES: n1cccc2nccnc12
2.InChI: InChI=1/C7H5N3/c1-2-6-7(9-3-1)10-5-4-8-6/h1-5H
3.InChIKey:YEYHFKBVNARCNE-UHFFFAOYAE

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravenous	180mg/kg (180mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03516,