Detail of "322-46-3"

Reference

Synthesis of pyrido[2,3-b]pyrazines from pyrido[2,3-c]furoxan

Synthesis of pyrido[2,3-b]pyrazines from pyrido[2,3-c]furoxan. Takabatake, Tohru; Miyazawa, Tomoyuki; Hasegawa, Minoru (Coll. 186794-84-3 are also occured in this study. Pharm., Nihon Univ., Chiba 274, Japan). Heterocycles, 45(1), 107-118 (English) 1997 Japan Institute of Heterocyclic Chemistry. CODEN: HTCYAM. ISSN: 0385-5414. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Pyrido[2,3-b]pyrazine 1,4-dioxides and pyrido[2,3-b]pyrazine 1-oxides were obtained from pyrido[2,3-c]furoxan and 1,3-diketones or b-keto esters catalyzed by silica gel, alumina, or mol. sieves. .

Synthesis and biological evaluation of pyrido[2,3-b]pyrazine and pyrido[2,3-b]pyrazine-N-oxide as selective glycine antagonists

Synthesis and biological evaluation of pyrido[2,3-b]pyrazine and pyrido[2,3-b]pyrazine-N-oxide as selective glycine antagonists. Cugola, Alfredo; Donati, Daniele; Guarneri, M.; Micheli, Fabrizio; Missio, Andrea; Pecunioso, Angelo; Reggiani, Angelo; Tarzia, G.; Zanirato, V. (Glaxo Wellcome S.p. 185677-07-0 is the cas registry number. This chemical is also mentioned in this article.A., Medicines Research Center, Verona 37100, Italy). Bioorganic & Medicinal Chemistry Letters, 6(22), 2749-2754 (English) 1996 Elsevier. CODEN: BMCLE8. ISSN: 0960-894X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 28 Pyrido[2,3-b]pyrazines and pyrido[2,3-b]pyrazines-N-oxides have been synthesized and evaluated for in vitro/in vivo antagonistic activity at the glycine site on the NMDA receptor. Efforts to improve the glycine vs. AMPA selectivity focussed on both arom. substitution and on modification of the heterocyclic ring. The compds. showed a good affinity for the glycine binding site and > 100-fold selectivity vs. the AMPA receptor. .