CAS No.32233-40-2,(-)-Corey lactone diol Suppliers,MSDS download

Products Categories

Pharmaceutical (195)
Organic Chemicals (33)
Others (23)
Reagent (4)
Materials (3)
Basic Inorganic Chemicals (2)
Agrochemicals (1)
Catalyst and Auxiliary (1)

Basic Information

Molecular Structure:
CAS No.:	32233-40-2
Name:	(-)-Corey lactone diol
Article Data:	30

Formula:	C₈H₁₂O₄
Molecular Weight:	172.181
Synonyms:	2H-Cyclopenta[b]furan-2-one,hexahydro-5-hydroxy-4-(hydroxymethyl)-, [3aR-(3aa,4a,5b,6aa)]-;2H-Cyclopenta[b]furan-2-one, hexahydro-5-hydroxy-4-(hydroxymethyl)-,stereoisomer (8CI);
EINECS:	608-721-8
Density:	1.365 g/cm³
Melting Point:	117-119 °C(lit.)
Boiling Point:	406.6 °C at 760 mmHg
Flash Point:	172.9 °C
Appearance:	white to beige-brown cryst. powder or crystals
Risk Codes:	R24/25
Safety:	24/25
PSA:	66.76000
LogP:	-0.70880

Synthetic route

: 58707-50-9, 72777-85-6, 81203-78-3, 65025-94-7
(3aR,4S,5R,6aS)-4-((tert-butyldimethylsilyloxy)methyl)-5-hydroxyhexahydro-2H-cyclopenta[b]furan-2-one

: 32233-40-2
(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In dichloromethane at 20℃; for 0.833333h; atmospheric pressure;	99%
Multi-step reaction with 2 steps 1: 90 percent / PPTS / 1,2-dichloro-ethane / 2 h / Ambient temperature 2: 3,4-Dihydro-2H-pyran / TsOH View Scheme

: 39746-00-4
(1S,5R,6S,7R)-7-benzoyloxy-6-hydroxymethyl-2-oxabicyclo[3.3.0]octan-3-one

: 32233-40-2
(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one

Conditions

Conditions	Yield
Stage #1: (1S,5R,6S,7R)-7-benzoyloxy-6-hydroxymethyl-2-oxabicyclo[3.3.0]octan-3-one With sodium methylate In methanol at 20℃; for 1.5h; Stage #2: With hydrogenchloride In 1,4-dioxane; methanol at 20℃; pH=3 - 4;	97%
With sodium methylate In methanol at 20℃; for 2h;	95%

: 117624-93-8
(1S,5R,6R,7R)-6-<<(tert-butyldimethylsilyl)oxy>methyl>-7-<(tert-butyldimethylsilyl)oxy>-2-oxabicyclo<3.3.0>octane-3-one

: 32233-40-2
(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one

Conditions

Conditions	Yield
With copper(ll) sulfate pentahydrate In methanol at 100℃; for 0.25h; Microwave irradiation;	96%
With cerium (IV) sulfate tetrahydrate In methanol at 60℃; for 12h;	96%
With aluminium(III) chloride hexahydrate In methanol at 100℃; for 0.25h; Solvent; Microwave irradiation; Sealed tube; chemoselective reaction;	95%

: 26054-65-9
(1S,5R,6R,7R)-(-)-2-oxa-6-(hydroxymethyl)-7-acetoxybicyclo<3.3.0>-octan-3-one

: 32233-40-2
(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one

Conditions

Conditions	Yield
With Amberlite IR 120 resin In methanol at 70℃; for 8h;	86%

: 31752-99-5
(-)-Corey lactone 5-(4-phenylbenzoate)

: 32233-40-2
(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one

Conditions

Conditions	Yield
With potassium carbonate In methanol; dichloromethane for 3h; Ambient temperature;	85%
Multi-step reaction with 4 steps 1: 94 percent / imidazole / dimethylformamide / 1 h / Ambient temperature 2: 65 percent / CH3ONa / methanol / 1.33 h / Ambient temperature 3: 90 percent / PPTS / 1,2-dichloro-ethane / 2 h / Ambient temperature 4: 3,4-Dihydro-2H-pyran / TsOH View Scheme

: Biphenyl-4-carboxylic acid (3aR,4S,5R,6aS)-5-hydroxy-2-oxo-hexahydro-cyclopenta[b]furan-4-ylmethyl ester

: 32233-40-2
(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran; methanol for 4h; Ambient temperature;	83%

: 62939-82-6
(3aR,4S,5R,6aS)-5-(acetyloxy)-4-[(acetyloxy)methyl]hexahydro-2H-cyclopenta[b]furan-2-one

: 32233-40-2
(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one

Conditions

Conditions	Yield
With Amberlite IR 120 resin In methanol at 70℃; for 8h;	82%
With hydrogenchloride In methanol; water for 4h; Reflux;	82.1%
With DBN In methanol at 20℃; for 12h;
With methanol at 25 - 65℃;	28 g

: 57930-46-8
(1S,5R,6R,7R)-(-)-6-acetoxymethyl-7-hydroxy-2-oxabicyclo<3.3.0>octan-3-one

: 32233-40-2
(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one

Conditions

Conditions	Yield
With Amberlite IR 120 resin In methanol at 70℃; for 8h;	82%
With resin Wofatit SBW (OH-) In methanol for 2h; Ambient temperature;	79%

: 50-00-0
formaldehyd

: 26054-46-6
(-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one

: 32233-40-2
(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one

Conditions

Conditions	Yield
Stage #1: formaldehyd; (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one With formic acid; sulfuric acid at 80℃; for 24h; Stage #2: With potassium carbonate In methanol at 0 - 20℃; for 2h;	79%

: 109122-52-3
(4aS,4bR,7aS,8aR)-Hexahydro-furo[3',2':3,4]cyclopenta[1,2-d][1,3]dioxin-6-one

A: 32233-40-2
(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one

B: 534-15-6
1,1-dimethoxyethane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In methanol at 75 - 80℃; for 4h;	A 78% B n/a

Raw Materials

50-00-0

Downstream Products

551-11-1

Total:179 Page 1 of 5 1 2 3 4 5 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 32233-40-2

Chemistry

Molecular Structure of 2H-Cyclopenta[b]furan-2-one,hexahydro-5-hydroxy-4-(hydroxymethyl)-, (3aR,4S,5R,6aS)- (CAS NO.32233-40-2):

IUPAC Name: (3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one
Empirical Formula: C₈H₁₂O₄
Molecular Weight: 172.18
H bond acceptors: 4
H bond donors: 2
Freely Rotating Bonds: 3
Polar Surface Area: 66.76 Å²
Index of Refraction: 1.545
Molar Refractivity: 39.88 cm³
Molar Volume: 126 cm³
Surface Tension: 54.6 dyne/cm
Density: 1.365 g/cm³
Flash Point: 176.7 °C
Enthalpy of Vaporization: 77.2 kJ/mol
Boiling Point: 415.2 °C at 760 mmHg
Vapour Pressure: 1.25E-08 mmHg at 25°C
Melting point: 117-119 °C(lit.)
Storage temp: -20°C
Product Categories: Prostaglandins; Latanoprost

Safety Profile

Safety Statements: 24/25
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3

Specification

2H-Cyclopenta[b]furan-2-one,hexahydro-5-hydroxy-4-(hydroxymethyl)-, (3aR,4S,5R,6aS)- , with CAS number of 32233-40-2, can be called Corey lactone diol;(3ar,4s,5r,6as)-(-)-hexahydro-5-hydroxy-4-(hydroxymethyl)-2h-cyclopent a[b]furan-2-one ; (3ar,4s,5r,6as)-hexahydro-5-hydroxy-4-(hydroxymethyl)-2h-cyclopenta[b]furan-2-one ; (-)-6beta-hydroxymethyl-7alpha-hydroxy-cis-2-oxabicyclo[3.3.0]octan-3-one ; (3ar,4s,5r,6as)-(-)-hexahydro-5-hydroxy- 4-hoch2-2h-cyclopenta(b)furan-2-one, 98%;hexahydro-5-hydroxy-4-(hydroxymethyl)-2h-cyclopenta[b]furan-2-one. ; (-)-corey diol (corey lactone) ; (-)-6beta-hydroxymethyl-7alpha-hydroxy-cis-2-oxabicyclo[3.3.0]octan-3-one .It is a white to beige-brown cryst. powder or crystal .

Premium Related Products

(-)-Corey lactone diol