Detail of "32462-30-9"

Reference

Cardiac hypertrophy in the dog and rat induced by oxfenicine, an agent which modifies muscle metabolism

Cardiac hypertrophy in the dog and rat induced by oxfenicine, an agent which modifies muscle metabolism. Greaves, P.; Martin, J.; Michel, M. C.; Mompon, P. (Cent. Rech., Lab. Pfizer, Amboise 37401, Fr.). Arch. Toxicol., Suppl., 7(Dis. Metab. Reprod. Toxic Response Drugs Other Chem.), 488-93 (English) 1984. CODEN: ATSUDG. ISSN: 0171-9750. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Oxfenicine (S-4-hydroxyphenyl glycine)(I) [32462-30-9] has been shown to protect the rat and dog heart from exptl. induced myocardial ischemia probably as a result of its ability to divert myocardial metab. from fatty acid to carbohydrate utilization with a consequent redn. in O consumption. When various dose levels of oxfenicine were administered to dogs for periods of up to 1 yr and rats for periods of up to 2 yr, dose-related increases in cardiac wt. were obsd. No increases in cardiac wt. were obsd. in the dogs after a similar treatment period. Macroscopic, light, histochem., and electron microscopic examn. of the myocardium revealed that the increase in heart wt. was due to uniform myocardial fiber hypertrophy involving all cardiac chambers. Individual muscle fibers were increased in size but there was no clear disproportion of mitochondria and myofibrils. Although intracellular lipid was increased, vacuolated lysosomal structures were only occasionally obsd. No histochem. differences in lysosomal enzyme activity were obsd. between the treated and the control rats. The structural changes were fully compatible with myocardial hypertrophy due to the decreased energy forming capacity of heart muscle resulting from inhibition of fatty acid oxidn. by oxfenicine.

Optical resolution of N-acyl-p-hydroxy-DL-phenylglycine

Optical resolution of N-acyl-p-hydroxy-DL-phenylglycine. Kimura, Hitoshi; Ookuma, Kazuhiko (Nippon Soda Co., Ltd., Japan). Japan. Kokai JP 52130987 2 Nov 1977 Showa, 10 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C12D013-06. APPLICATION: JP 76-46221 23 Apr 1976. DOCUMENT TYPE: Patent CA Section: 16 (Fermentations) N-acyl-p-hydroxy-DL-phenylglycine was asym. hydrolyzed to p-hydroxy-L-phenylglycine (I) [32462-30-9] and N-acyl-p-hydroxy-D-phenylglycine, catalyzed by cells or enzyme prepns. of Alternaria. Thus, 400 mL enzyme ext. of mold-bran of A. kikuchiana IFO 5243 was added to 600 mL soln. contg. 50 g N-chloroacetyl-p-hydroxy-DL-phenylglycine [52067-89-7] and reacted at 37° for 135 h. The reaction soln. was treated with active C and extd. with EtOAc at pH 1-2. The ext. was washed with satd. NaCl, dried with addn. of MgSO4, and evapd. to obtain 24.5 g cryst. N-chloroacetyl-p-hydroxy-D-phenylglycine [52152-38-2]. The aq. layer in the EtOAc extn. was evapd. in vacuo at pH 5 to obtain 9.4 g cryst. I.