Detail of "3252-43-5"

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CAS Number:
3252-43-5
Name:
Acetonitrile,2,2-dibromo-
Molecular Structure:
Formula:
C2H Br2 N
Molecular Weight:
198.86
Synonyms:
Acetonitrile,dibromo- (6CI,7CI,8CI,9CI); Dibromoacetonitrile
EINECS:
221-843-2
Density:
2.434g/cm³
Boiling Point:
163.1°Cat760mmHg
Flash Point:
31.9°C
Hazard Symbols:
Risk Codes:
20/21/22-36-22
Safety:
Poison by intravenous route. Questionable carcinogen with experimental carcinogenic data. Experimental reproductive effects. Human mutation data reported. See also NITRILES and BROMIDES. When heated to decomposition it emits very toxic fumes of NO_x, Br⁻, and CN⁻. Details

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Relationship between the metabolism of haloacetonitriles and chloroform and their carcinogenic activity: Relationship between the metabolism of haloacetonitriles and chloroform and their carcinogenic activity. Pereira, M. A.; Daniel, F. B.; Lin, E. L. C. (Health Eff. Res. Lab., Cincinnati, OH, USA). Report, EPA/600/D-84/203; Order No. PB84-246230, 19 pp. Avail. NTIS From: Gov. Rep. Announce. Index (U. S.) 1984, 84(26), 74 (English) 1984. DOCUMENT TYPE: Report CA Section: 4 (Toxicology) The metab. of halogenated acetonitriles was investigated in relation to their possible carcinogenic activity. Chloroacetonitrile) [107-14-2], dibromoacetonitrile (DBAN) [3252-43-5], dichloroacetonitrile (DCAN) [3018-12-0], bromochloroacetonitrile [83463-62-1], and trichloroacetonitrile [545-06-2] were shown to bind the nucleophilic trapping agent, p-nitrobenzylpyridine [1083-48-3] without metabolic activation and to produce strand-breaks in DNA of cultured human CCRF-CEM cells. In addn., DCAN bound DNA in vitro without metabolic activation and DBAN bound rat liver DNA following oral administration.

Carcinogenic activity of haloacetonitriles and haloacetone derivatives in the mouse skin and lung: Carcinogenic activity of haloacetonitriles and haloacetone derivatives in the mouse skin and lung. Bull, R. J.; Robinson, M. (Health Eff. Res. Lab., Cincinnati, OH, USA). Report, EPA-600/D-84-185; Order No. PB84-215508, 19 pp. Avail. NTIS From: Gov. Rep. Announce. Index (U. S.) 1984, 84(21), 79 (English) 1984. DOCUMENT TYPE: Report CA Section: 4 (Toxicology) The carcinogenicity in mouse skin and lung of chloro- [107-14-2], dichloro- [3018-12-0], trichloro- [545-06-2], bromochloro- [83463-62-1], and dibromoacetonitrile [3252-43-5] and of 1,1-dichloro- [513-88-2] and 1,1,1-trichloroacetone [918-00-3] was studied. The haloacetonitriles found in drinking water, with the possible exception of the dichloro compd., possessed carcinogenic properties. It was not possible to demonstrate such activity with the chlorinated acetones.