Detail of "32527-55-2"

Reference

Antinephritic effect of tiaramide on experimental nephritis in rats (1)

Antinephritic effect of tiaramide on experimental nephritis in rats (1). Ito, Mikio; Saito, Naoto; Nagamatsu, Tadashi; Suzuki, Yoshio (Fac. Pharm., Meijo Univ., Japan). Ensho, 3(4), 413-14 (Japanese) 1983. CODEN: ENSHEE. ISSN: 0389-4290. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Tiaramide (I) [32527-55-2] (50 or 100 mg/kg/day, orally) given to rats with nephritis inhibited urinary protein excretion and decreased blood level of cholesterol. Studies on the glomerular histopathol. parameters showed that I at 100 mg/kg/day decreased mesangium growth index by 18.5% and epithelial crescent formation index by >50%. I, unlike indomethacin, had no side effects on the digestive tract and hematopoietic app. and seemed to be effective upon prolonged administration.

Anti-inflammatory activity of tiaramide hydrochloride

Anti-inflammatory activity of tiaramide hydrochloride. Hiroi, Jun; Ohara, Kaname; Takashima, Toshiyuki; Kikuchi, Hiroyuki (Res. Lab., Fujisawa Pharm. Co., Ltd., Japan). Ensho, 3(4), 411-12 (Japanese) 1983. CODEN: ENSHEE. ISSN: 0389-4290. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Tiaramide [32527-55-2] showed antiinflammatory activity against carrageenin-induced edema in rat paws, and its activity was comparable to that of phenylbutazone, aspirin, and benzydamine. However, tiaramide had greater activities against allergy- and serotonin-induced edema than did the comparative drugs. The mechanism of tiaramide antiinflammatory activity seemed to involve the inhibition of platelet aggregation and the antagonism against chem. mediators, esp. prostaglandins.