Detail of "3254-39-5"

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The effect of monovalent cations on the association behavior of guanosine 5'-monophosphate, cytidine 5'-monophosphate, and their equimolar mixture in aqueous solution

The effect of monovalent cations on the association behavior of guanosine 5'-monophosphate, cytidine 5'-monophosphate, and their equimolar mixture in aqueous solution. Walmsley, Judith A.; Sagan, Barbara L. (Dep. Chem., Univ. Toledo, Toledo, OH 43606, USA). Biopolymers, 25(11), 2149-72 (English) 1986. CODEN: BIPMAA. ISSN: 0006-3525. DOCUMENT TYPE: Journal CA Section: 6 (General Biochemistry) 1H- and 31P-NMR spectroscopy were used to investigate the self-assocn. of M2(5'-CMP) [M = Li+, Na+, K+, Rb+, or (CH3)4N+], the self-assocn. of Li2(5'-GMP), and the heteroassocn. of 5'-GMP and 5'-CMP (1:1 mol ratio) in aq. soln. as a function of the nature of the monovalent cation. Proton spectral differences for the different 5'-CMP salts exhibit a cation-size dependence and were ascribed to a change in the stacking geometry. An av. stacking assocn. const. of 0.63 M-1 at 1°, consistent with the weak stacking interactions of the cytosine bases, was detd. for the 5'-CMP salts. Heteroassocn. of 5'-GMP and 5'-CMP follows the reverse of the cation order for the formation of ordered aggregates of 5'-GMP. Heteroassocn. occurs in the presence of Li+, Na+, and Rb+, but only self-assocn. occurs for the K+ nucleotides. Li2(5'-GMP), which does not form ordered species, self-assocs. to form disordered base stacks with a stacking const. 3254-39-5 and 6757-06-8 are just another two chemicals used in this study. of 1.63 M-1 at 1°. .