Reference

Acute toxicity of chemicals used in the household

Acute toxicity of chemicals used in the household. I. Suzuki, Yasuo; Naito, Katsuji; Tobe, Masuo (Natl. Inst. Hyg. Sci., Tokyo 158, Japan). Eisei Shikensho Hokoku, (101), 152-6 (Japanese) 1983. CODEN: ESKHA5. ISSN: 0077-4715. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Oral LD50s of 8 chems. used in the household were detd. in rats. The values (mg/kg) were 13,000 (male) and 13,200 (female) for N-methyloldimethylphosphonopropionamide [20120-33-6], 308 (male) and 245 (female) for 1,3-di[tris(hydroxymethyl)phosphoniummethyl]urea [87957-27-5], 48.4 (male) and 63.5 (female) for phenylmercuric oleate [104-60-9], >20,000 (male, female) for N-methyl-4-methoxynaphthalimide [3271-05-4], >20,000 (male, female) for Na dialkyl sulfosuccinate (66%: distearate, 34%: palmitate), 6600 (male) and 5800 (female) for Na alkyl sulfate (55%: oleate, 45: palmitate), 11,300 (male) and 13,000 (female) for distearyldimethylammonium chloride [107-64-2], >15,000 (male, female) for the condensate between stearic acid diethylenetriamine and urea. Depression of spontaneous movement, piloerection, diarrhea, or hypothermia was obsd. in animals of all groups during testing.

Toxicity of N-methyl-4-methoxynaphthalimide, a fluorescent whitening agent

Toxicity of N-methyl-4-methoxynaphthalimide, a fluorescent whitening agent. Otake, Toru; Aburada, Satoshi; Nishimura, Hiroshi; Nakamura, Seiichi; Ugawa, Masahiro; Takagi, Yasuhiro; Akasaka, Susumu; Ikegami, Nobuko (Osaka Pref. Inst. Public Health, Osaka 537, Japan). Arch. Environ. Contam. Toxicol., 16(1), 119-27 (English) 1987. CODEN: AECTCV. ISSN: 0090-4341. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Toxicol. studies on N-methyl-4-methoxynaphthalimide (MMNI)(I) [3271-05-4], a water pollutant, were performed on mice for acute toxicity, and on rats for distribution and subacute toxicity. The mutagenicity of MMNI and its metabolites in bacteria was also investigated. Seven days of consecutive administration with MMNI to male rats caused accumulation of MMNI in the adipose tissue, large intestine, and liver.In this article, certain chemicals are used. Some of their cas registry numbers are 9000-86-6 and 9035-51-2 Small amts. of MMNI were detected in the kidneys, spleen, thymus, and serum, and the metabolites of MMNI were detected primarily in the serum and liver, although they were rapidly excreted from the body by urinary routes. The LD50 value in male mice by i.p. administration of MMNI was 7700 mg/kg. No growth retardation was found in rats orally administered for 21 days. Male rats fed on 30,000 ppm and female rats fed on 6700 or 30,000 ppm MMNI exhibited slight growth retardation after a 40-day feeding trial. Enlargement of rat livers was seen in the high dose groups (100 mg/day, 6700 and 30,000 ppm), along with moderate histol. changes in liver (such as fatty infiltration, focal necrosis, proliferation of endoplasmic reticulum, and Mallory's bodies). Histol. changes were also detected in kidneys (vacuolation and numerous hyalin droplets in the tubules) and pancreas (vacuolation). In these groups, mean amts. of serum protein were elevated, and serum glutamic-pyruvic transaminase activities were decreased. Atrophy of thymus was seen in the 6700 and 30,000-ppm group, but an immunosuppressive effect was not obsd. An increase in the amts. of liver cytochrome P 450 [9035-51-2] was found in the rats given 10 and 100 mg daily doses of MMNI for 21 days. There was no mutagenic activity of MMNI on the Salmonella typhimurium TA98 and TA100 with or without S-9 mix, whereas its metabolites present in the urine of rats had slight mutagenic activity on TA100. .