Reference

A new parenteral vehicle for the administration of some poorly water soluble anti-cancer drugs

A new parenteral vehicle for the administration of some poorly water soluble anti-cancer drugs. Tarr, Bryan D.; Yalkowsky, Samuel H. (Coll. Pharm., Univ. Arizona, Tucson, AZ, USA). J. Parenter. Sci. Technol., 41(1), 31-3 (English) 1987. CODEN: JPATDS. ISSN: 0279-7976. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) A new parenteral vehicle was developed for 3 poorly water sol. anticancer drugs, taxol [33069-62-4], 3,5-dichloro-2,4-dimethoxy-6-trichloromethylpyridine [108030-77-9], and 2-(S-chloromethylthio)quinoline [62601-19-8], using Pluronic L64 [106392-12-5]. A tertiary cosolvent system contg. pluronic L64 (60%), ethanol [64-17-5] (30%), and polysorbate 80 [9005-65-6] (10%) was formulated. All 3 drugs tested were stable in this vehicle. Methods of administration usually involve a simple diln. of 1 part formulation with 2 parts water. The water-dild. formulation of the 3 drugs studied is phys. stable for 3 days prior to crystn.Except for chemicals metioned above, 64-17-5 and 62601-19-8 are also used. .

Verapamil reversal of vincristine resistance and cross-resistance patterns of vincristine-resistant chinese hamster ovary cells

Verapamil reversal of vincristine resistance and cross-resistance patterns of vincristine-resistant chinese hamster ovary cells. Brewer, F.; Warr, J. R. (Biol. Dep., Univ. York, Heslington/York Y01 5DD, UK). Cancer Treat. Rep., 71(4), 353-9 (English) 1987. CODEN: CTRRDO. ISSN: 0361-5960. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The phenotypic properties of a large no. of low-level vincristine (VCR) [57-22-7]-resistant Chinese hamster ovary cell lines have been studied. In particular, the correlation between the reversal of VCR resistance by verapamil (VRP) [52-53-9] and cross-resistance patterns to other drugs were examd. 53643-48-4 and 51-21-8 are also in the experiment. Cross-resistance to other vinca alkaloids developed in parallel with VCR resistance. Doxorubicin [23214-92-8] resistance was obsd. in many of the cell lines, occurring even at the lowest levels of VCR resistance. Increased sensitivity to taxol (TAX) [33069-62-4] was a feature of half of the lines tested and there was no increased resistance to 5-fluorouracil [51-21-8] or chlorambucil [305-03-3]. Two main groups of mutants have been identified: (a) those that are thought to be membrane mutants which are cross-resistant to TAX and whose VCR resistance is reversible by VRP; and (b) those that appear to be tubulin mutants, which have increased sensitivity to TAX and resistance to VCR in the presence of VRP. It was not possible to distinguish between the different mechanisms of low-level resistance by drug accumulation studies in unsupplemented medium. However, VCR accumulation in the presence of VRP did correlate with the cross-resistance results. .