Detail of "33089-74-6"

Reference

Bacterial degradation products of the ixodicide amitraz

Bacterial degradation products of the ixodicide amitraz. Allcock, E. R.; Woods, D. R.; Rivett, D. E. A. (Dep. Microbiol., Rhodes Univ., Grahamstown, S. Afr.). J. Appl. Bacteriol., 44(3), 383-6 (English) 1978. CODEN: JABAA4. ISSN: 0021-8847. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The nature and order of appearance of the degrdn. products of amitraz (I) [33089-61-1] by mixed bacterial cultures were investigated. The primary pathway involved the conversion of I to 2,4-dimethylaniline [95-68-1]. A slower secondary pathway involved the conversion of I to 2,4-dimethylaniline via the intermediates N-2,4-dimethylphenyl-N'-methylformamidine [33089-74-6] and 2,4-dimethylformanilide [60397-77-5]. The bacterial degrdn. pathway of I differs from that found in plants and animals.

Actions of formamidines, local anesthetics, octopamine and related compounds upon the electrical activity of neurohemal organs of the stick insect (Carausius morosus) and sense organs of fly larvae (Musca domestica; Calliphora erythrocephala)

Actions of formamidines, local anesthetics, octopamine and related compounds upon the electrical activity of neurohemal organs of the stick insect (Carausius morosus) and sense organs of fly larvae (Musca domestica; Calliphora erythrocephala). Osborne, Michael P. (Med. Sch., Univ. Birmingham, Birmingham B15 2TJ, UK). Pestic. Biochem. Physiol., 23(2), 190-204 (English) 1985. CODEN: PCBPBS. ISSN: 0048-3575. DOCUMENT TYPE: Journal CA Section: 5 (Agrochemical Bioregulators) Section cross-reference(s): 12 The pesticides, chlordimeform [6164-98-3] and amitraz [33089-61-1], and their metabolites, demethylchlordimeform [21787-80-4], N1-(2,4-dimethylphenyl)-N-methylformamidine [33089-74-6], and 2,4-dimethylformanilide [60397-77-5], are effective at concns. as low as 3 mM in raising the firing rate of endogenously active neurosecretory fibers in the isolated neurohemal organs of C. morosus. Mols. such as bunamidine [3748-77-4] and cetrimide [8044-71-1], with cationic detergent properties, produced sporadic bursting which did not elevate the overall firing rate to any great extent. Indeed, bunamidine could induce complete block of action potentials at concns. 330 mM. The local anesthetics, procaine [59-46-1], lidocaine [137-58-6], and benzocaine [94-09-7], do not block the activity at least up to a level of 1 mM. They have no effect at concns. <100 mM. Between 100 mM and 1 mM lidocaine and benzocaine produce a small increase in firing rate. Procaine produced a pronounced increase in the frequency of firing. The phenolic amines, octopamine [104-14-3], synephrine [16589-24-5], and tyramine [51-67-2], markedly increased elec. activity. The catecholamines, dopamine [51-61-6], noradrenaline [51-41-2], and adrenaline [51-43-4], by contrast, only produced a weak excitation. Neither a- or b-adrenergic blocking agents were effective in antagonizing the elec. activity induced by chlordimeform or phenolic amines until relatively high concns. of about 1 mM were used. Chlordimeform was able to induce high-frequency bursts from sense organs assocd. with the epidermis and body-wall musculature in larvae of Musca domestica and Calliphora erythrocephala. Octopamine did not induce any similar bursting activity in these sense organs. These results are discussed in relationship to current views on the mode of action of the N-aryl amidines. Thus the excitatory effects of these compds. upon neurohemal organs and sense organs are more likely to result from a direct action upon voltage-sensitive channels of the nerve membranes, rather than by an effect mediated by interactions with octopamine receptors.