Detail of "331-25-9"

CAS Number:
331-25-9
Name:
3-Fluorophenylacetic acid
Molecular Structure:
Formula:
C₈H₇FO₂
Molecular Weight:
154.14
Synonyms:
2-(3-Fluorophenyl)acetic acid;(3-Fluorophenyl)acetic acid;
EINECS:
206-360-7
Density:
1.272 g/cm³
Melting Point:
42-44 °C(lit.)
Boiling Point:
256.1 °C at 760 mmHg
Flash Point:
108.7 °C
Appearance:
White to pale yellow or light beige crystalline
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety:
22-24/25-36-26 Details

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Reference

New progesterone derivatives as inhibitors of 5a-reductase enzyme and prostate cancer cell growth: All Rights Reserved. New progesterone derivatives as inhibitors of 5a-reductase enzyme and prostate cancer cell growth. Cabeza, Marisa; Bratoeff, Eugene; Heuze, Ivonne; Rojas, Arely; Teran, Nayely; Ochoa, Martha; Ramirez-Apan, M. 918331-44-9 and 331-25-9 which are cas registry numbers of chemicals are mentioned. A. Teresa; Ramirez, Elena; Perez, Victor; Gracia, Isabel (Department of Biological Systems and Animal Production Metropolitan University-Xochimilco, Mexico, Mex.). Journal of Enzyme Inhibition and Medicinal Chemistry, 21(4), 371-378 (English) 2006 Informa Healthcare. CODEN: JEIMAZ. ISSN: 1475-6366. DOCUMENT TYPE: Journal CA Section: 32 (Steroids) Section cross-reference(s): 2 The synthesis and pharmacol. evaluation, in vivo as well as in vitro, of four new progesterone derivs. I and II (R = Ph, 2-F-C6H4, 3-F-C6H4) are reported. The evaluation in vivo was carried out on gonadectomized male hamsters that were injected s.c. daily with 1 mg/kg of testosterone (T) and/or 1 mg/kg of finasteride, or with 2 mg/kg of the novel compds. When testosterone (T) and finasteride or compd. I were injected together, the wt. of the prostate decreased significantly as compared of testosterone-treated animals. Compds. II did not show in vivo activity. The 5a-reductase inhibitory activity of the novel compds. was detd. in vitro using human prostate homogenates. The steroids inhibited the 5a-reductase activity with IC50 values lower than that for the ref. compd. finasteride. The effect of the compds. on the growth of lymphocytes and prostate cancer culture cells line was that steroid I inhibited the growth of both cells lines at a concn. of 50 mM and showed a cytotoxic effect whereas compds. II showed a much lower inhibition. Nevertheless the steroids did not exhibit toxic effects in vivo since the animals remained alive during the 6 days of treatment. .

Detail of "331-25-9"

3-Fluorophenylacetic acid

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CAS No.331-25-9 3-Fluorophenylacetic acid

CAS No.331-25-9 3-Fluorophenylacetic acid

CAS No.331-25-9 3-Fluorophenylacetic acid

CAS No.331-25-9 3-Fluorophenylacetic acid

CAS No.331-25-9 3-Fluorophenylacetic acid

CAS No.331-25-9 3-Fluorophenylacetic acid

CAS No.331-25-9 3-Fluorophenylacetic acid

CAS No.331-25-9 3-Fluorophenylacetic acid

CAS No.331-25-9 3-Fluorophenylacetic acid

CAS No.331-25-9 3-Fluorophenylacetic acid

CAS No.331-25-9 3-Fluorophenylacetic acid

CAS No.331-25-9 3-Fluorophenylacetic acid

CAS No.331-25-9 3-Fluorophenylacetic acid

CAS No.331-25-9 3-Fluorophenylacetic acid

CAS No.331-25-9 3-Fluorophenylacetic acid

CAS No.331-25-9 3-Fluorophenylacetic acid

CAS No.331-25-9 3-Fluorophenylacetic acid

CAS No.331-25-9 3-Fluorophenylacetic acid

CAS No.331-25-9 3-Fluorophenylacetic acid

CAS No.331-25-9 3-Fluorophenylacetic acid

CAS No.331-25-9 3-Fluorophenylacetic acid

Reference