Detail of "33178-86-8"

Reference

Interactions between alinidine and responses to acetylcholine, dopamine and 5-hydroxytryptamine of specific Helix central neurons

Interactions between alinidine and responses to acetylcholine, dopamine and 5-hydroxytryptamine of specific Helix central neurons. Bokisch, Anita J.; Walker, R. J. (Sch. Biochem. Physiol. Sci., Univ. Southampton, Southampton S09 3TU, UK). Br. J.Several reagents with their cas registry numbers 50-67-9 and 7440-23-5 are used here. Pharmacol., 80(3), 567-71 (English) 1983. CODEN: BJPCBM. ISSN: 0007-1188. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 Intracellular recordings were made from identified neurons in the brain of the snail Helix aspersa. The effect of alinidine [33178-86-8] on the excitatory and inhibitory responses to acetylcholine [51-84-3] and dopamine [51-61-6] and on the excitatory response to 5-HT [50-67-9] was investigated. Alinidine decreased the responses to acetylcholine and 5-HT and the excitatory response to dopamine but had no effect on the dopamine inhibitory response. The pA2 values against the excitatory responses of acetylcholine, dopamine and 5-HT were 5.8, 5.6 and 5.5, resp. The pA2 value against acetylcholine inhibition was 3.5. Alinidine appears to interact preferentially with the Na ionophore, to a lesser degree with the Cl- ionophore and not at all with the K+ ionophore on Helix central neurons. .

Alinidine

Alinidine. Kobinger, Walter; Lillie, Christian (Ernst-Boehringer-Inst. Arzneimittelforsch., Vienna, Austria). New Drugs Annu.: Cardiovasc. Drugs, 2 193-210 (English) 1984. CODEN: NDADD8. ISSN: 0742-387X. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) A review with 57 refs. on the cardiovascular pharmacol. of alinidine [33178-86-8].