Reference

Preventive effect of saponins from leaves of 'taranoki' (Alalia elata) on carbon tetrachloride-induced liver injury

Preventive effect of saponins from leaves of 'taranoki' (Alalia elata) on carbon tetrachloride-induced liver injury. Nishida, Keiji; Higuchi, Tetsuya; Nagamura, Yoichi; Ito, Madoka; Ishiguro, Isao; Sumita, Shigeya; Saito, Setsuo (Sch. Med., Fujita Health Univ., Toyoake 470-11, Japan). Igaku to Seibutsugaku, 123(6), 271-5 (Japanese) 1991. CODEN: IGSBAL. ISSN: 0019-1604. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The preventive effect of saponins from leaves of Aralia elata (I, R = H, rhamosyl; R1 = H, glucosyl, R2 = Me, CH2OH) on CCl4-induced liver injury was examd. in male ddY mice. The inhibition rate of ES-8 I (R = a-L-rhamosyl; R1 = H; R2 = CH2OH), (1.0 mmol/kg) on the leakage of aspartate aminotransferase (AST) and alanine aminotranserase from liver was 30.39 and 25.05%, resp., vs. 11.02 and 16. 140360-29-8 and 33289-85-9 which are cas registry numbers of substances are two of reagents here.45% for inhibition by glycyrrhizin, while the inhibition rate of ES-7, I (R = R1 = H; R2 = Me), was higher than glycyrrhizin against only AST (18.59%). The mechanism of action is under investigation. .