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CAS No.: | 3335-98-6 |
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Name: | 1-Phenyloxindole |
Article Data: | 43 |
Molecular Structure: | |
Formula: | C14H11NO |
Molecular Weight: | 209.247 |
Synonyms: | 2-Indolinone,1-phenyl- (7CI);Oxindole, 1-phenyl- (6CI);1,3-Dihydro-1-phenyl-2H-indol-2-one;1-Phenyl-1,3-dihydro-2H-indol-2-one;1-Phenyl-2-indolinone;1-Phenyloxindole;N-Phenyl-2-indolinone;NSC 234518; |
EINECS: | 1312995-182-4 |
Density: | 1.228 g/cm3 |
Melting Point: | 123-125 °C |
Boiling Point: | 443.6 °C at 760 mmHg |
Flash Point: | 222.7 °C |
Solubility: | 74.3mg/L at 20℃ |
Appearance: | White or white powder category |
Hazard Symbols: | Xi |
PSA: | 20.31000 |
LogP: | 2.97240 |
1-phenyl-1,3-dihydro-indol-2-one
Conditions | Yield |
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With trifluoroacetic anhydride Product distribution; Further Variations:; Reagents; | 100% |
Multi-step reaction with 4 steps 1: 98 percent / dimethylformamide / 4 h / 24 °C 2: 98 percent / Et3N; DMAP / CH2Cl2 / 3.5 h / 20 - 40 °C 3: 95 percent / hydrogen / Pd/C / methanol / 3 h / 30 °C 4: polyphosphoric acid / toluene / 11 h / 110 °C View Scheme |
2-diazo-N,N-diphenyl-acetamide
1-phenyl-1,3-dihydro-indol-2-one
Conditions | Yield |
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With [(S)-(2-phenyl-4-pheox)Ru(CH3CN)4]PF6 In dichloromethane at 20℃; for 0.0166667h; Inert atmosphere; regioselective reaction; | 99% |
Conditions | Yield |
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With palladium diacetate; triethylamine; johnphos In toluene at 80℃; for 3h; | 95% |
With aluminium trichloride at 180 - 190℃; for 0.166667h; | 81.5% |
With aluminium trichloride at 180 - 190℃; for 1h; | 75% |
Conditions | Yield |
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With hydrazine hydrate for 0.25h; Heating; | 92% |
Stage #1: 1-phenyl-indole-2,3-dione With potassium hydroxide; hydrazine In water; ethylene glycol at 160℃; for 1.5h; Stage #2: With hydrogenchloride In water; ethylene glycol | 90% |
With hydrazine hydrate In ethanol for 6h; Wolff-Kishner reduction; Heating; | 58% |
3-(methylthio)-1-phenylindolin-2-one
1-phenyl-1,3-dihydro-indol-2-one
Conditions | Yield |
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With nickel In ethanol for 2h; Heating; | 85% |
1-phenyl-1,3-dihydro-indol-2-one
Conditions | Yield |
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With sulfuric acid; tetrabutylammomium bromide In 5,5-dimethyl-1,3-cyclohexadiene at 100℃; for 16h; Solvent; Reagent/catalyst; | 84% |
Conditions | Yield |
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With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In 1,4-dioxane for 24h; Reflux; | 83% |
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In acetonitrile Reflux; Inert atmosphere; | 82% |
With potassium phosphate; copper(l) iodide In dimethyl sulfoxide at 130℃; for 24h; Ullmann Condensation; Inert atmosphere; Glovebox; | 41 %Chromat. |
With potassium phosphate; copper(l) iodide; 3-azapentane-1,5-diamine In dimethyl sulfoxide at 50℃; for 24h; Reagent/catalyst; Inert atmosphere; Glovebox; Sealed tube; | 27 %Chromat. |
2-(2-bromophenyl)-N-phenylacetamide
1-phenyl-1,3-dihydro-indol-2-one
Conditions | Yield |
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With caesium carbonate; XPhos; palladium diacetate In toluene at 100℃; for 0.5h; microwave irradiation; | 82% |
2-(2-chlorophenyl)-N-phenylacetamide
1-phenyl-1,3-dihydro-indol-2-one
Conditions | Yield |
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With caesium carbonate; XPhos; palladium diacetate In toluene at 100℃; for 0.5h; microwave irradiation; | 80% |
methyl (2-nitrophenyl)acetate
phenylboronic acid
1-phenyl-1,3-dihydro-indol-2-one
Conditions | Yield |
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With 1,2,2,3,4,4-hexamethylphosphetane 1-oxide; diphenylsilane In m-xylene at 120℃; for 4h; Catalytic behavior; Reagent/catalyst; Solvent; Inert atmosphere; Schlenk technique; Sealed tube; | 80% |
Molecular Structure of 2H-Indol-2-one,1,3-dihydro-1-phenyl- (CAS NO.3335-98-6):
IUPAC Name: 1-phenyl-3H-indol-2-one
Empirical Formula: C14H11NO
Molecular Weight: 209.2432
H bond acceptors: 2
H bond donors: 0
Freely Rotating Bonds: 1
Polar Surface Area: 20.31 Å2
Index of Refraction: 1.648
Molar Refractivity: 61.95 cm3
Molar Volume: 170.2 cm3
Surface Tension: 52.2 dyne/cm
Density: 1.228 g/cm3
Flash Point: 222.7 °C
Enthalpy of Vaporization: 70.13 kJ/mol
Boiling Point: 443.6 °C at 760 mmHg
Vapour Pressure: 4.56E-08 mmHg at 25°C
Melting point: 123-125°C
Product Categories: blocks; IndolesOxindoles; Indoline & Oxindole
Hazard Codes: Xi
Hazard Note: Irritant
HazardClass: Irritant
2H-Indol-2-one,1,3-dihydro-1-phenyl- , with CAS number of 3335-98-6, can be called 1,3-Dihydro-1-phenyl-2h-indol-2-one ; 1,3-dihydro-1-phenyl-2h-indole-2-one ; 1-phenyl-1,3-dihydro-2h-indol-2-one ; 1-phenyloxindole ; 1-phenylindolin-2-one;phenyloxindole ; n-phenyl-2-indolinone ; n-phenyloxindole .