Detail of "33396-37-1"

CAS Number:
33396-37-1
Name:
Bufa-4,20,22-trienolide,3-[(6-deoxy-4-O-methyl-a-L-mannopyranosyl)oxy]-14-hydroxy-, (3b)-
Superlist Name:
Meproscillarin
Molecular Structure:
Formula:
C31H44 O8
Molecular Weight:
544.75
Synonyms:
Bufa-4,20,22-trienolide,3b-[(6-deoxy-4-O-methyl-a-L-mannopyranosyl)oxy]-14-hydroxy-(8CI); Clift; Meproscillarin; Methyl proscillaridin; Methyl proscillaridin A;Proscillaridin 4-methyl ether
Density:
1.29g/cm³
Boiling Point:
709.8°Cat760mmHg
Flash Point:
227.5°C
Safety:
Poison by ingestion and intravenous routes. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. Details

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Elimination of meproscillarin by hemoperfusion: Elimination of meproscillarin by hemoperfusion. Rupp, M.; Brass, H.; Belz, G. G. (II. Med. Klin., Staedt. Krankenanstalten, Ludwigshafen, Ger.). Arzneim.-Forsch., 28(3A), 567-9 (German) 1978. CODEN: ARZNAD. ISSN: 0004-4172. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 4 Hemoperfusion of blood, to which meproscillarin (I) [33396-37-1] had been added, through a bed of polymer-coated active charcoal (Haemocol) removed >50% of the drug from the plasma. The removal occurred principally during the 1st h. The clearance of I was 87 mL/min in the 1st few min but had decreased after, 60 min to 6-7 mL/min. Therapy of cardiac glycoside poisoning by adsorption on active charcoal is discussed.

Stability in vitro of methylproscillaridin: Stability in vitro of methylproscillaridin. Bergdahl, B.; Andersson, K. E. (Dep. Clin. Pharmacol., Univ. Hosp., Linkoping, Swed.). Eur. J. Clin. Pharmacol., 11(4), 267-71 (English) 1977. CODEN: EJCPAS. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The vitro stability of methylproscillaridin (I) [33396-37-1] was compared with that of proscillaridin, the activities of the glycosides being assayed by the 86Rb-technique. After incubation in gastric juice at pH 1, 2, and 3, the activity half life of each glycoside was proportional to pH and was .apprx. 0.25 h, 2.5 h, and 25 h, resp. The inactivation rate in pure HCl at pH 2 did not differ from that in gastric juice of the same pH. The glycosides were stable in bile and enteric juice. In feces, I was stable and proscillaridin was inactivated with a half life of 32 h. Thus, the difference in biol. availability between the 2 glycosides cannot be explained by differences in gastrointestinal stability.