Reference

Enteric coated composition comprising prostaglandin analogs as chloride channel opener

Enteric coated composition comprising prostaglandin analogs as chloride channel opener. Ueno, Ryuji (Sucampo A.-G., Switz.). PCT Int.Some commonly used reagents like 333963-40-9 and 223569-58-2 are used in this experiment. Appl. WO 2005002588 A1 13 Jan 2005, 38 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: A61K031-5575. ICS: A61K009-28. APPLICATION: WO 2004-JP9867 5 Jul 2004. PRIORITY: US 2003-PV484304 3 Jul 2003. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) The present invention provides an enteric coated compn. for oral administration of a chloride channel opener which can provide improved pharmaceutical activity with reduced adverse side effect such as nausea. For example, the bicyclic 13,14-dihydro-16,16-difluoro-prostaglandin E1 had less side effect of nausea when deliveried by enteric coated capsules produced by spraying hydroxypropyl Me cellulose phthalate as enteric coating. .