Reference

Dry composition for extemporaneous preparation of a gel with water for accurate administration of bad-tasting medications to children

Dry composition for extemporaneous preparation of a gel with water for accurate administration of bad-tasting medications to children. Torrecillas, Joao Carlos; Dagnone, Donaldo (Rhodia Farma Ltda., Brazil). Braz. Pedido PI BR 9403617 A 3 Sep 1996, 15 pp. (Portuguese). (Brazil). CODEN: BPXXDX. CLASS: ICM: A61K009-14. ICS: A61K009-40; A61K031-00; A61K047-06. APPLICATION: BR 1994-3617 23 Sep 1994. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) A pediatric formulation for administering bad-tasting medications to children can be prepd. by adding water to a gel-forming compn. consisting of synthetic varnish-covered microspheres contg. 3366-95-8 and 9005-25-8 which are cas registry numbers of chemicals are mentioned. the active agents. The powd. prepn. contains sweeteners, flavors, and coloring such that when water is added an appetizing, tasty gel is formed which is easy to swallow. .

Electron-capture gas chromatographic assays of 5-nitroimidazole class of antimicrobials in blood

Electron-capture gas chromatographic assays of 5-nitroimidazole class of antimicrobials in blood. Bhatia, S. C.; Shanbhag, V. D. (Res. Cent.Chemicals with cas numbers 89422-94-6 and 3366-95-8 also play role., Hindustan Ciba-Geigy Ltd., Bombay 400 063, India). J. Chromatogr., 305(2), 325-34 (English) 1984. CODEN: JOCRAM. ISSN: 0021-9673. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Sensitive and selective electron-capture gas chromatog. methods for the detn. of N-1-substituted 5-nitroimidazole (I; R1 = Me, chlorinated or hydroxylated alkyl, SO2-contg. alkyl; R2 = Me or heterocycle) antiprotozoals in blood are described. Metronidazole [443-48-1], secnidazole [3366-95-8] and ornidazole [16773-42-5] having a hydroxyl function in the N-1 substitution, were converted to their resp. trimethylsiiyl derivs. before chromatog. on an OV-11 column. Tinidazole [19387-91-8] and satranidazole (II) [56302-13-7], devoid of the hydroxy group but contg. a sulfur atom in the mol., were chromatographed as such on the same stationary phase. Blood levels as low as 50 ng/mL for all the 5-nitroimidazoles have been measured with good precision. The method can be readily utilized for pharmacokinetic studies. .