Reference

Bicyclic benzenoid aminoalkylene ethers and thioethers as drugs

Bicyclic benzenoid aminoalkylene ethers and thioethers as drugs.. Studt, William L.; Kuhla, Donald E.; Campbell, Henry F. (Rorer, William H., Inc., USA). U.S. US 4588719 A 13 May 1986, 46 pp. Cont.-in-part of U.S. Ser. No. 604,813. (United States of America) CODEN: USXXAM. CLASS: ICM: A61K031-535. ICS: A61K031-135; C07C087-457; C07D295-12. NCL: 514212000. APPLICATION: US 84-664222 24 Oct 1984. PRIORITY: US 83-489702 29 Apr 1983; US 84-604813 27 Apr 1984. There are some commonly used reagents like 33892-75-0 in this article. DOCUMENT TYPE: Patent CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) Section cross-reference(s): 1 The title compds. I [R = N-bonded 5,6, or 7-membered heterocyclic ring optionally contg. addnl. hetero atoms (O,N,S); R1,R2,R3 = H, alkyl; X = O, S, sulfoxide, sulfone; Y = NHQ; R6 = H, alkyl; a = 0-2; b = 0,1; c = 0-3; d = 0,1; e = 2-4], useful as antisecretory, antihistaminic, antiulcer and cytoprotective agents, were prepd. Treatment of 5-[3-aminopropoxy)-1-(1-piperidinyl)indan in MeOH with 1,2-dimethoxycyclobutene-3,4-dione and then anhyd. NH3 gave I (R = 1-piperidinyl; R1 = R2 = R3 = H; X = O; R6 = H; a = b = d = 0; c = 1; e = 3), which demonstrated antiulcer activity in tests with male Sprague-Dawley rats. .

Preparation of ruthenium compounds having optically active diamine ligands as asymmetric reduction catalysts and process for preparation of optically active alcohols

Ooka, Hirohito; Inoue, Tsutomu (Nippon Soda Co., Ltd., Japan). PCT Int. Appl. WO 2004007506 A1 22 Jan 2004, 59 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW, AM, AZ, BY, KG, KZ, MD, RU, TJ, TM; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (Japanese). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07F009-50. ICS: C07C029-145; C07C035-36; C07C035-52; C07C041-26; C07C043-23; C07C211-18; C07C211-27; C07C211-29; C07C217-58; C07C231-18; C07C233-73; C07D317-28; B01J031-24; C07F015-00.Some commonly used reagents like 647027-96-1 and 33892-75-0 are used in this experiment. APPLICATION: WO 2002-JP7168 15 Jul 2002. DOCUMENT TYPE: Patent CA Section: 78 (Inorganic Chemicals and Reactions) Ruthenium compds. represented by the general formula Ru(X)(Y)(Px)n1[R1R2C*1(NR3R4)-A-R5R6C*2(NR7R8)] [I; X, Y = H, halo, CO2H, HO, C1-20 alkoxy; Px = a phosphine ligand; R1-R8 = H, each (un)substituted C1-20 alkyl, C2-20 alkenyl, C3-8 cycloalkyl, C7-20 aralkyl, or aryl; or R1 and R3 and/or R5 and R7 are linked to each other to form a ring; A = each (un)substituted C1-8 alkylene,C2-8 alkylene contg. 1-2 O atom(s), C3-8 cycloalkylene, arylene, or divalent heterocyclic group; when A is alkylene, R2 and R6 are bonded to each other to form a ring; at least one carbon atom selected from among carbon atoms of C*1 and C*2 is optically active] are prepd. Also disclosed is a process for the prepn. of optically active alcs. by asym. redn. of a fused-ring ketone or an a-amino ketone by the use of such a ruthenium compd. I as asym. redn. catalyst. Thus, 1 mg (2R,5R)-2,5-diaminohexane hydrochloride (0.005 mmol), 0.37 g tetralone (2.5 mmol), 75 mL 1 M KOH/isopropanol, and 1.5 mL isopropanol were added to an 100 mL autoclave, degassed, treated with 5 mg RuCl2[(S)-Tol-BINAP]-DMF adduct (0.005 mmol), pressurized with H at 8 atm, and stirred for 1.5 h to give, after silica gel chromatog., 64% (R)-1,2,3,4-tetrahydro-1-naphthol (91% ee). .