Detail of "33924-49-1"

Reference

Method for preparation of glibenclamide

Method for preparation of glibenclamide.In this study， 16673-34-0 and 33924-49-1 are also used. Hwang, Ui Hyeong; Jang, Hae Seong; Jung, Geun Hoe; Kim, Dae Hwang; Kim, Seon Ok; Ko, Yeong Gwan; Koo, Dong Wan; Ryu, Jae Uk; Woo, Jae Chun (Korea Research Institute of Chemical Technology, S. Korea). Repub. Korean Kongkae Taeho Kongbo KR 2002083568 A 4 Nov 2002, No pp. given (Korean). (Korea, Republic Of). CODEN: KRXXA7. CLASS: ICM: C07C317-32. APPLICATION: KR 2001-22944 27 Apr 2001. DOCUMENT TYPE: Patent CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) Provided is a method for economically synthesizing glibenclamide, with powder shape, which is used as an intermediate for synthesis of medicine useful for treatment of diabetes. The method comprises the steps of (i) reacting N-phenethyl-5-chloro-2-methoxybenzamide with chlorosulfonic acid(ClSO3H) represented by formula 2 in the presence of thionyl chloride(SOCl2) to form p-(N-phenethyl-5-chloro-2-methoxybenzamide)sulfonylchloride represented by formula 3; (ii) reacting sulfonylchloride compd. represented by formula 3 with ammonia to form p-(N-phenethyl-5-chloro-2-methoxybenzamide)sulfoneamide represented by formula 4; (iii) reacting sulfoneamide compd. represented by formula with alkali metal hydroxide in the presence of alc. solvent to form p-(N-phenethyl-5-chloro-2-methoxybenzamide)sulfone amide-metal salt represented by formula 5; and (iv) reacting the metal represented by formula 5 with cyclohexyl isocyanate or phenylcyclohexyl carbamate to form glibenclamide represented by formula 1. .