Detail of "340-90-9"

Reference

Syntheses and properties of N-(1,3-diisocyanato-1-propyl)phthalimide and its polymers

Syntheses and properties of N-(1,3-diisocyanato-1-propyl)phthalimide and its polymers. Yang, Chin-Ping; Iwakura, Yoshio; Uno, Keikichi; Toda, Fujio (Fac. Eng., Univ. Tokyo, Tokyo, Japan). Makromol. Chem., 177(12), 3495-514 (English) 1976. CODEN: MACEAK. DOCUMENT TYPE: Journal CA Section: 35 (Synthetic High Polymers) Section cross-reference(s): 25 Monomeric N-(1,3-diisocyanato-1-propyl)phthalimide (I) [61745-43-5] was prepd. by treating 2-phthalimido-L-glutamic acid [340-90-9] with SOCl2 to form the dichloride [36805-71-7], and reacting the dichloride with NaN3 to obtain 2-phthalimidoglutamoyl diazide [61745-42-4], followed by a Curtius rearrangement. I was a viscous, transparent liq. that could be purified by mol. distn. without racemization. Polyureas, polyurethanes, and a poly(urea-urethane) were prepd. from I, and their thermal properties and solubilities were detd. All the polymers decomposed at 200-50.degree..

Embryotoxic interactions between a hydrolysis product of thalidomide and the surfactant Tween 20 in mice

Embryotoxic interactions between a hydrolysis product of thalidomide and the surfactant Tween 20 in mice.Some chemicals with cas registry numbers like 340-90-9 and 50-35-1 are also used. Kocher-Becker, Ursula; Kocher, Walter; Ockenfels, Heinrich (Inst. Toxikol. Embryonalpharmakol., Freie Univ. Berlin, Berlin D-1000/33, Germany). Z. Naturforsch., C: Biosci., 47(1-2), 155-69 (German) 1992. CODEN: ZNCBDA. ISSN: 0341-0382. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 2 N,N-Phthaloyl-L-glutamic acid (NPLG), a hydrolysis product of thalidomide, and the surfactant Tween 20 were co-administered i.p. to pregnant NMRI mice on days 9 and 82/3 post coitus at doses where the hydrolysis product as well as the surfactant alone induce minimal embryotoxicity. The combined substances (350 mg/kg NPLG + 1.0 mL/kg Tween 20) caused a potentiative teratogenic and an additive embryolethal response. Enhancement of the amt. of Tween 20 in the combinations to 2.5 mL/kg led to the same potentiative teratogenic and, in addn., potentiative embryolethal response. Distribution studies using 14C-NPLG showed a strongly increased NPLG content in the maternal plasma under the influence of 2.5 mL/kg Tween 20 but not after co-administration with 1.0 mL/kg Tween 20. The malformations obtained were of the same type in all groups and mostly located in the vertebrae and ribs. .