Detail of "34068-01-4"

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Phenylethanolamine derivatives and their acid addition salts for enhancing the growth rate of meat-producing animals and improving the efficiency of feed utilization

Phenylethanolamine derivatives and their acid addition salts for enhancing the growth rate of meat-producing animals and improving the efficiency of feed utilization. Baker, Pamela K.; Kiernan, Jane A. (American Cyanamid Co.In this study， 88151-14-8 and 34068-01-4 are also used. , USA). U.S. US 4404222 A 13 Sep 1983, 25 pp. Cont.-in-part of U.S. Ser. No. 181,254, abandoned. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-275; A61K031-135; A61K031-42; A61K031-40. NCL: 424304000. APPLICATION: US 80-219054 22 Dec 1980. PRIORITY: US 79-66908 16 Aug 1979; US 80-143069 24 Apr 1980; US 80-181254 25 Aug 1980. DOCUMENT TYPE: Patent CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) Section cross-reference(s): 5, 17 The animal growth-promoting title compds. I (R = H, C1-4 alkyl; R1 = H, C3-6 alkyl, C3-4 alkenyl; R2 = H, C1-6 alkyl, cyclohexyl, MeOCH2CH2CH2, C3-4 alkenyl, Ph; R1R2N = morpholino, 4-alkylpiperazino; R3 = H, HO, alkoxy, acyloxy, alkylthio; R4 = H, halo, cyano; R5 = H, (un)substituted amino; R6 = H, halo, HO, cyano, CF3, CO2H, alkoxycarbonyl, CONH2, C1-4 alkyl, C1-4 alkoxy, NO2, dialkylaminomethyl, HOCH2) were prepd. Thus, brominating 3,3-Cl2C6H3COMe followed by reductive cyclization gave 3,4-dichlorostyrene oxide, which was treated with Me3CNH2 to give I (R = R1 = R5 = H, R2 = Me3C, R2 = HO, R4 = R6 = Cl). At 0.50 ppm in feed I (R = R1 = H, R2 = Me3C, R = HO, R4 = R6 = Cl, R5 = H2N) increased growth wt. in poultry by 3.7%, and enhanced deposition of muscle tissue. .